小动物关节炎压缩模型。
Small-Animal Compression Models of Osteoarthritis.
机构信息
University of California Davis Health, Department of Orthopaedic Surgery, Sacramento, CA, USA.
Purdue University, Weldon School of Biomedical Engineering, West Lafayette, IN, USA.
出版信息
Methods Mol Biol. 2023;2598:345-356. doi: 10.1007/978-1-0716-2839-3_25.
Abstract
The utility of nonsurgical, mechanical compression-based joint injury models to study osteoarthritis pathogenesis and treatments is increasing. Joint injury may be induced via cyclic compression loading or acute overloading to induce anterior cruciate ligament rupture. Models utilizing mechanical testing systems are highly repeatable, require little expertise, and result in a predictable onset of osteoarthritis-like pathology on a rapidly progressing timeline. In this chapter, we describe the procedures and equipment needed to perform mechanical compression-induced initiation of osteoarthritis in mice and rats.
摘要
非手术性、基于机械压缩的关节损伤模型在研究骨关节炎发病机制和治疗方法方面的应用正在增加。关节损伤可以通过循环压缩加载或急性超负荷来诱导前交叉韧带断裂。利用机械测试系统的模型具有高度可重复性，需要的专业知识较少，并且可以在快速进展的时间内预测性地引发类似骨关节炎的病理学。在本章中，我们描述了在小鼠和大鼠中进行机械压缩诱导骨关节炎起始所需的程序和设备。
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