胶原酶诱导的小鼠骨关节炎。
Collagenase-Induced Osteoarthritis in Mice.
机构信息
Experimental Rheumatology, Department of Rheumatology, Interdisciplinary Consortium for Clinical Movement Sciences and Technology (ICMS), Radboud Medical Centre, Nijmegen, The Netherlands.
出版信息
Methods Mol Biol. 2023;2598:375-379. doi: 10.1007/978-1-0716-2839-3_27.
The collagenase-induced experimental osteoarthritis model is in general applied in mice but can also be used in other small species. The model is mainly based on the induction of joint laxity but has also a major inflammatory component. In this chapter, the induction is described by two injections of collagenase at the start of the model. Investigators who will use this model have to have ample experience in intra-articular injection in mice.
胶原酶诱导的实验性骨关节炎模型通常应用于小鼠，但也可用于其他小型物种。该模型主要基于关节松弛的诱导，但也具有主要的炎症成分。在本章中，通过在模型开始时两次注射胶原酶来描述诱导。使用这种模型的研究人员必须在小鼠关节内注射方面有丰富的经验。
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