Collagenase-Induced Osteoarthritis in Mice.

The collagenase-induced experimental osteoarthritis model is in general applied in mice but can also be used in other small species. The model is mainly based on the induction of joint laxity but has also a major inflammatory component. In this chapter, the induction is described by two injections of collagenase at the start of the model. Investigators who will use this model have to have ample experience in intra-articular injection in mice.