Kim Chan-Young, Kim Hyeong-Geug, Lee Hye Won, Seol In-Chan, Kim Yoon-Sik, Choi Hyung Il, Park Miso S, Yoo Ho-Ryong
Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University, Daejeon 34520, Korea.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Pharmaceuticals (Basel). 2022 Nov 9;15(11):1375. doi: 10.3390/ph15111375.
(JGT), a traditional herbal medicine, has been used to treat dizziness and vertigo in Korea and China for hundreds of years. The purpose of this study was to evaluate the pharmacological properties of JGT in chronic subjective dizziness (CSD) patients. A randomized, double-blind, parallel-group and placebo-controlled trial was performed with a total of 50 CSD patients. The patients were randomly assigned to one of two groups: JGT or placebo ( = 25 for each). All participants received the treatment (placebo or JGT, 24 g/day) for 4 weeks. We analyzed the serum levels of oxidative stressors, antioxidants, and stress hormones. Serum levels of lipid peroxidation, but not nitric oxide, were significantly decreased in the JGT group. JGT not only prevented the decline of serum total glutathione contents and total antioxidant capacity, but it also increased superoxide dismutase and catalase activities. Serum levels of stress hormones including cortisol, adrenaline, and serotonin were notably normalized by JGT treatment, but noradrenaline levels were not affected. Regarding the safety and tolerability of JGT, we found no allergic, adverse, or side effects in any of the participants. JGT showed beneficial effects on CSD patients by improving redox status and balancing psycho-emotional stress hormones.
荆芥穗（JGT）是一种传统草药，在韩国和中国已被用于治疗头晕和眩晕数百年。本研究的目的是评估JGT对慢性主观性头晕（CSD）患者的药理特性。对总共50例CSD患者进行了一项随机、双盲、平行组和安慰剂对照试验。患者被随机分配到两组之一：JGT组或安慰剂组（每组25例）。所有参与者接受治疗（安慰剂或JGT，24克/天），为期4周。我们分析了氧化应激物、抗氧化剂和应激激素的血清水平。JGT组中脂质过氧化的血清水平显著降低，但一氧化氮水平未降低。JGT不仅防止了血清总谷胱甘肽含量和总抗氧化能力的下降，还增加了超氧化物歧化酶和过氧化氢酶的活性。JGT治疗使包括皮质醇、肾上腺素和血清素在内的应激激素的血清水平显著恢复正常，但去甲肾上腺素水平未受影响。关于JGT的安全性和耐受性，我们在任何参与者中均未发现过敏、不良或副作用。JGT通过改善氧化还原状态和平衡心理情绪应激激素，对CSD患者显示出有益作用。
