Hepatology Department, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon, 34929, South Korea.
The K-herb Research Centre, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Arch Toxicol. 2017 Dec;91(12):4009-4015. doi: 10.1007/s00204-017-2007-9. Epub 2017 Jun 20.
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7. All these participants were women and developed the hepatocellular type of HILI. One HILI participant met the criteria for Hy's law; however, none of six cases presented clinical symptoms related to liver injury. This is the first nationwide prospective study that estimated the extent of the incidence of HILI [total: 0.60%, 95% confidence interval (CI) 0.12-1.08; women: 0.95%, 95% CI 0.19-1.68] and described its features in hospitalized participants.
关于草药诱导的肝损伤 (HILI) 的发生率，已经有报道存在差异。为了解决全球范围内对 HILI 的日益关注，我们在一项全国性的前瞻性研究中评估了 HILI 的风险。在 2013 年 4 月至 2016 年 1 月期间，来自韩国 10 家三级医院的 1001 名住院患者（360 名男性和 641 名女性）接受了草药治疗，并定期测量了他们的肝酶。共有 6 名患者符合 HILI 的标准，RUCAM 评分为 4 至 7 分。所有这些参与者均为女性，发生了肝细胞型 HILI。1 名 HILI 患者符合 Hy's 法则的标准；然而，在这 6 例病例中，没有任何病例出现与肝损伤相关的临床症状。这是第一项估计 HILI 发生率的全国性前瞻性研究[总发生率：0.60%，95%置信区间 (CI) 0.12-1.08；女性：0.95%，95% CI 0.19-1.68]，并描述了住院患者的特征。
