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罕见的戈登链球菌致人工关节感染病例报告。

A Rare Case of Prosthetic Joint Infection with Streptococcus gordonii.

机构信息

Department of Internal Medicine, Community Memorial Health Systems, Ventura, CA, USA.

Department of Orthopedic Surgery, Community Memorial Health Systems, Ventura, CA, USA.

出版信息

Am J Case Rep. 2022 Nov 10;23:e937271. doi: 10.12659/AJCR.937271.

DOI:10.12659/AJCR.937271
PMID:36355628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9664417/
Abstract

BACKGROUND Chronic prosthetic joint infection (PJI) is a devastating complication following total joint arthroplasty, resulting in significant morbidity and mortality. The criterion standard of treatment for chronic PJI is two-stage revision arthroplasty consisting of complete hardware removal, thorough irrigation and debridement, placement of an antibiotic spacer, prolonged intravenous antibiotics based on culture sensitivities, and revision total knee arthroplasty once the infection resolves. The most common organism implicated in chronic PJI is Staphylococcus aureus. CASE REPORT In this report, we have summarized the case of a 75-year-old woman who developed chronic PJI caused by an unusual organism, Streptococcus gordonii, 1 year after a right total knee arthroplasty. S. gordonii is a gram-positive organism that is an oral flora and a colonizer of human teeth. This organism is known to create biofilm on the human teeth, more commonly known as dental plaque. S. gordonii has the ability to travel to extraoral sites and cause infection. It has been found to be a cause of subacute bacterial endocarditis, but it has been rarely described in the literature as a cause of prosthetic joint infection. Treatment of S. gordonii requires a tailored approach. CONCLUSIONS This case report highlights the clinical presentation, diagnosis, and treatment of chronic prosthetic joint infection caused by S. gordonii and identifies a rare cause of PJI that is not well documented in the literature. Streptococcal PJI portends a poorer prognosis, and identification of this organism is crucial for prompt treatment and improved outcomes for PJI.

摘要

背景

慢性人工关节感染(PJI)是全关节置换术后一种毁灭性的并发症,导致发病率和死亡率显著增加。慢性 PJI 的标准治疗方法是两阶段翻修术,包括彻底清除所有硬件、彻底冲洗和清创、放置抗生素间隔器、根据培养结果使用静脉注射抗生素进行长时间治疗,以及一旦感染得到控制,再次进行全膝关节翻修术。最常与慢性 PJI 相关的病原体是金黄色葡萄球菌。

病例报告

本报告总结了一位 75 岁女性的病例,她在右膝关节初次置换 1 年后,因罕见病原体戈登链球菌(Streptococcus gordonii)引起慢性 PJI。戈登链球菌是一种革兰氏阳性菌,存在于口腔中,也是人类牙齿的定植菌。这种细菌会在人类牙齿上形成生物膜,通常被称为牙菌斑。戈登链球菌有能力转移到口腔外的部位并引起感染。它已被发现是亚急性细菌性心内膜炎的病因,但在文献中很少被描述为人工关节感染的病因。治疗戈登链球菌感染需要采取个体化的方法。

结论

本病例报告强调了由戈登链球菌引起的慢性人工关节感染的临床表现、诊断和治疗,并确定了一种文献中未充分记录的罕见 PJI 病因。链球菌性 PJI 预后较差,及时识别该病原体对于改善 PJI 的治疗效果至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/b4ff2fa5c7bf/amjcaserep-23-e937271-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/29ebabd03e29/amjcaserep-23-e937271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/5059f0210bd4/amjcaserep-23-e937271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/b4ff2fa5c7bf/amjcaserep-23-e937271-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/29ebabd03e29/amjcaserep-23-e937271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/5059f0210bd4/amjcaserep-23-e937271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9664417/b4ff2fa5c7bf/amjcaserep-23-e937271-g003.jpg

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本文引用的文献

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Biofilm properties in relation to treatment outcome in patients with first-time periprosthetic hip or knee joint infection.生物膜特性与初次人工髋关节或膝关节假体周围感染患者治疗结果的关系
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septic arthritis of the glenohumeral joint following deltoid intramuscular vaccination.三角肌肌内接种后盂肱关节化脓性关节炎。
BMJ Case Rep. 2021 May 25;14(5):e243066. doi: 10.1136/bcr-2021-243066.
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Rare Occurrence of Prosthetic Knee Septic Arthritis Due to Streptococcus viridans in the Background of a Dental Procedure.
在牙科手术背景下,草绿色链球菌导致人工膝关节感染性关节炎的罕见病例
Cureus. 2019 Oct 24;11(10):e5980. doi: 10.7759/cureus.5980.
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Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis.戈登链球菌 I 型脂磷壁酸有助于表面蛋白生物发生。
mSphere. 2019 Dec 4;4(6):e00814-19. doi: 10.1128/mSphere.00814-19.
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Biology of Oral Streptococci.口腔链球菌的生物学特性
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Mortality During Total Knee Periprosthetic Joint Infection.全膝关节假体周围关节感染的死亡率。
J Arthroplasty. 2018 Dec;33(12):3783-3788. doi: 10.1016/j.arth.2018.08.021. Epub 2018 Aug 25.
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High Cure Rate for Acute Streptococcal Prosthetic Joint Infections Treated With Debridement, Antimicrobials, and Implant Retention in a Specialized Tertiary Care Center.在一家专业的三级保健中心,清创术、抗菌药物治疗和保留假体治疗急性链球菌性人工关节感染的治愈率高。
Clin Infect Dis. 2018 Sep 28;67(8):1288-1290. doi: 10.1093/cid/ciy335.
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Spondylodiskitis and endocarditis due to Streptococcus gordonii.戈登链球菌致椎间盘炎和心内膜炎。
Ann Clin Microbiol Antimicrob. 2017 Oct 4;16(1):68. doi: 10.1186/s12941-017-0243-8.
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