Department of Internal Medicine, Community Memorial Health Systems, Ventura, CA, USA.
Department of Orthopedic Surgery, Community Memorial Health Systems, Ventura, CA, USA.
Am J Case Rep. 2022 Nov 10;23:e937271. doi: 10.12659/AJCR.937271.
BACKGROUND Chronic prosthetic joint infection (PJI) is a devastating complication following total joint arthroplasty, resulting in significant morbidity and mortality. The criterion standard of treatment for chronic PJI is two-stage revision arthroplasty consisting of complete hardware removal, thorough irrigation and debridement, placement of an antibiotic spacer, prolonged intravenous antibiotics based on culture sensitivities, and revision total knee arthroplasty once the infection resolves. The most common organism implicated in chronic PJI is Staphylococcus aureus. CASE REPORT In this report, we have summarized the case of a 75-year-old woman who developed chronic PJI caused by an unusual organism, Streptococcus gordonii, 1 year after a right total knee arthroplasty. S. gordonii is a gram-positive organism that is an oral flora and a colonizer of human teeth. This organism is known to create biofilm on the human teeth, more commonly known as dental plaque. S. gordonii has the ability to travel to extraoral sites and cause infection. It has been found to be a cause of subacute bacterial endocarditis, but it has been rarely described in the literature as a cause of prosthetic joint infection. Treatment of S. gordonii requires a tailored approach. CONCLUSIONS This case report highlights the clinical presentation, diagnosis, and treatment of chronic prosthetic joint infection caused by S. gordonii and identifies a rare cause of PJI that is not well documented in the literature. Streptococcal PJI portends a poorer prognosis, and identification of this organism is crucial for prompt treatment and improved outcomes for PJI.
慢性人工关节感染(PJI)是全关节置换术后一种毁灭性的并发症,导致发病率和死亡率显著增加。慢性 PJI 的标准治疗方法是两阶段翻修术,包括彻底清除所有硬件、彻底冲洗和清创、放置抗生素间隔器、根据培养结果使用静脉注射抗生素进行长时间治疗,以及一旦感染得到控制,再次进行全膝关节翻修术。最常与慢性 PJI 相关的病原体是金黄色葡萄球菌。
本报告总结了一位 75 岁女性的病例,她在右膝关节初次置换 1 年后,因罕见病原体戈登链球菌(Streptococcus gordonii)引起慢性 PJI。戈登链球菌是一种革兰氏阳性菌,存在于口腔中,也是人类牙齿的定植菌。这种细菌会在人类牙齿上形成生物膜,通常被称为牙菌斑。戈登链球菌有能力转移到口腔外的部位并引起感染。它已被发现是亚急性细菌性心内膜炎的病因,但在文献中很少被描述为人工关节感染的病因。治疗戈登链球菌感染需要采取个体化的方法。
本病例报告强调了由戈登链球菌引起的慢性人工关节感染的临床表现、诊断和治疗,并确定了一种文献中未充分记录的罕见 PJI 病因。链球菌性 PJI 预后较差,及时识别该病原体对于改善 PJI 的治疗效果至关重要。