Division of Psychiatry, University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK.
Division of Psychology and Language Sciences, University College London, 26 Bedford Way, London WC1H 0AP, UK.
Ageing Res Rev. 2023 Jan;83:101782. doi: 10.1016/j.arr.2022.101782. Epub 2022 Nov 7.
This study aimed to systematically review and meta-analyse the prevalence of sleep disturbances in people with dementia and examine demographic predictors and whether overall prevalence has changed over time. We searched Embase, MEDLINE and PsycINFO for studies reporting the prevalence of sleep disturbances in people with dementia living at home. We meta-analysed the data and calculated the pooled prevalence of sleep disturbances in people with dementia overall and in dementia subtypes. We used meta-regressions to investigate the effects of study characteristics, publication dates and participant demographics. Eleven studies fulfilled the inclusion criteria. The pooled prevalence of any symptoms of sleep disturbance was 26 % (95 % confidence intervals, CI: 23-30 %; n = 2719) and of clinically significant sleep disturbance 19 % (13-25 %; n = 2753). The pooled prevalence of sleep disturbance symptoms was significantly lower among people with Alzheimer's disease (24 %; 16-33 %, n = 310) than Lewy body dementia (49 %; 37-61 %, n = 65). Meta-regression analysis did not find that publication year, participant's age, sex and study quality predicted prevalence. Sleep disturbances are common among people with dementia living in the community, especially in Lewy body dementia. There was no change in prevalence according to publication dates, suggesting treatment has not improved over time.
本研究旨在系统地综述和荟萃分析痴呆患者睡眠障碍的患病率，并探讨人口统计学预测因素，以及总体患病率是否随时间发生变化。我们在 Embase、MEDLINE 和 PsycINFO 中搜索了报告居家痴呆患者睡眠障碍患病率的研究。我们对数据进行荟萃分析，并计算了痴呆患者整体和各亚型睡眠障碍的汇总患病率。我们使用荟萃回归分析来探讨研究特征、发表日期和参与者人口统计学的影响。有 11 项研究符合纳入标准。任何睡眠障碍症状的总患病率为 26%（95%置信区间，CI：23-30%；n=2719），临床显著睡眠障碍的患病率为 19%（13-25%；n=2753）。在阿尔茨海默病患者（24%；16-33%，n=310）中，睡眠障碍症状的总患病率明显低于路易体痴呆（49%；37-61%，n=65）。荟萃回归分析未发现发表年份、参与者年龄、性别和研究质量可以预测患病率。睡眠障碍在社区中生活的痴呆患者中很常见，尤其是在路易体痴呆患者中。根据发表日期，患病率没有变化，这表明治疗并没有随着时间的推移而改善。
