Department of Pathology, McGill University, Montréal, QC, Canada.
Division of Plastic & Reconstructive Surgery, Department of Surgery, McGill University Health Centre, Montréal, QC, Canada.
Int J Surg Pathol. 2023 Jun;31(4):464-471. doi: 10.1177/10668969221102551. Epub 2022 Nov 10.
Breast implant-associated anaplastic large cell lymphoma (breast implant-associated ALCL) is a recently described, distinct clinicopathological entity associated with macrotextured breast implants. The diagnostic workup of a patient suspected to have breast implant-associated ALCL includes cytological assessment of effusions and tissue biopsies of any masses or enlarged lymph nodes, with morphologic and immunophenotypic evaluation and possible flow cytometric and molecular testing. We report the case of a woman found to have breast implant-associated ALCL on fine needle aspirate and core biopsy, who on surgical resection, had extensive local disease with involvement of the resection margins and lymph nodes, requiring systemic treatment. We focus on the flow cytometric findings that identified a population of large cells on the CD30/side scatter dot plot and whose immunophenotype was consistent with breast implant-associated ALCL, highlighting the value of flow cytometry as an adjunct to morphological and immunophenotypic evaluation.
乳房植入物相关间变性大细胞淋巴瘤（乳房植入物相关 ALCL）是一种最近描述的、与粗糙纹理乳房植入物相关的独特临床病理实体。怀疑患有乳房植入物相关 ALCL 的患者的诊断工作包括对积液进行细胞学评估，以及对任何肿块或增大的淋巴结进行组织活检，进行形态学和免疫表型评估，并可能进行流式细胞术和分子检测。我们报告了一例在细针抽吸和核心活检中发现乳房植入物相关 ALCL 的女性病例，该患者在手术切除时发现广泛的局部疾病，包括切除边缘和淋巴结受累，需要全身治疗。我们重点介绍了流式细胞术检测结果，该结果在 CD30/侧向散射点图上识别出一群大细胞，其免疫表型与乳房植入物相关 ALCL 一致，突出了流式细胞术作为形态学和免疫表型评估的辅助手段的价值。
