Miranda Amalia, Akpobolokemi Tamara, Chung Etelka, Ren Guogang, Raimi-Abraham Bahijja Tolulope
Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, King's College London, Waterloo Campus, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK.
School of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK.
Antibiotics (Basel). 2022 Nov 10;11(11):1592. doi: 10.3390/antibiotics11111592.
Plant-mediated green synthesis is a cost-effective and eco-friendly process used to synthesize metallic nanoparticles. Experimental pH is of interest due to its ability to influence nanoparticle size and shape; however, little has been explored in comparison to the influence of this parameter on the therapeutic potential of resultant metallic nanoparticles. Our work investigated the influence of pH alternation on antimicrobial properties of plant-mediated green synthesized (using leaf extract) silver nanoparticles. We further investigated if the antimicrobial activity was sustained at 8 weeks (after initial green synthesis). Antimicrobial properties were evaluated against and Our work confirmed that experimental pH in plant-mediated green synthesis of silver nanoparticles influenced their resultant antimicrobial properties. Silver nanoparticles generated at experimental pH 4,5, and nine showed activity against which was sustained at various levels over 8 weeks. No antimicrobial activity was observed against and weak antimicrobial activity against These interesting findings highlight the importance of experimental pH. Further understanding of the role experimental pH plays on resultant metallic nanoparticle properties as it relates to biological and therapeutic impact is required, which will have an impact on wider applications beyond antimicrobial activity.
植物介导的绿色合成是一种用于合成金属纳米颗粒的经济高效且环保的过程。实验pH值因其能够影响纳米颗粒的大小和形状而备受关注；然而，与该参数对所得金属纳米颗粒治疗潜力的影响相比，相关研究较少。我们的工作研究了pH值变化对植物介导的绿色合成（使用叶提取物）银纳米颗粒抗菌性能的影响。我们进一步研究了抗菌活性在初始绿色合成后8周是否持续。针对[具体菌种1]和[具体菌种2]评估了抗菌性能。我们的工作证实，植物介导的银纳米颗粒绿色合成过程中的实验pH值会影响其最终的抗菌性能。在实验pH值为4、5和9时生成的银纳米颗粒对[具体菌种1]表现出活性，并在8周内不同程度地持续存在。对[具体菌种2]未观察到抗菌活性，对[具体菌种3]的抗菌活性较弱。这些有趣的发现凸显了实验pH值的重要性。需要进一步了解实验pH值在所得金属纳米颗粒性能方面所起的作用，因为这与生物和治疗影响相关，这将对抗菌活性之外的更广泛应用产生影响。
