Drosouni Andrianna, Panagopoulou Maria, Aidinis Vassilis, Chatzaki Ekaterini
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Institute of Agri-Food and Life Sciences, Hellenic Mediterranean University Research Centre, 71410 Heraklion, Greece.
Cancers (Basel). 2022 Nov 4;14(21):5437. doi: 10.3390/cancers14215437.
Autotaxin (ATX), the protein product of Ectonucleotide Pyrophosphatase Phosphodiesterase 2 (), is a secreted lysophospholipase D (lysoPLD) responsible for the extracellular production of lysophosphatidic acid (LPA). ATX-LPA pathway signaling participates in several normal biological functions, but it has also been connected to cancer progression, metastasis and inflammatory processes. Significant research has established a role in breast cancer and it has been suggested as a therapeutic target and/or a clinically relevant biomarker. Recently, methylation was described, revealing a potential for clinical exploitation in liquid biopsy. The current review aims to gather the latest findings about aberrant signaling through ATX-LPA in breast cancer and discusses the role of expression and epigenetic modification, giving insights with translational value.
自分泌运动因子（ATX）是胞外核苷酸焦磷酸酶/磷酸二酯酶2（ENPP2）的蛋白质产物，是一种分泌型溶血磷脂酶D（lysoPLD），负责溶血磷脂酸（LPA）的细胞外生成。ATX-LPA信号通路参与多种正常生物学功能，但也与癌症进展、转移和炎症过程有关。大量研究已证实其在乳腺癌中的作用，并有人提出将其作为治疗靶点和/或具有临床相关性的生物标志物。最近，有人描述了（此处原文似乎不完整，可能有信息缺失）甲基化，揭示了其在液体活检中的临床应用潜力。本综述旨在收集有关乳腺癌中通过ATX-LPA异常信号传导的最新发现，并讨论（此处原文似乎不完整，可能有信息缺失）表达和表观遗传修饰的作用，提供具有转化价值的见解。
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