School of Life Science and Health Engineering, Jiangnan University, No. 1800, Lihu Avenue, Wuxi 214122, China.
Bloomage Biotechnology Corporation Limited, Jinan 250101, China.
Biomolecules. 2022 Oct 28;12(11):1582. doi: 10.3390/biom12111582.
Alginate hydrogel has received great attention in diabetic wound healing. However, the limited tunability of the ionic crosslinking method prevents the delicate management of physical properties in response to diverse wound conditions. We addressed this issue by using a microgel particle (fabricated by zinc ions and coordinated through the complex of carboxymethyl chitosan and aldehyde hyaluronic acid) as a novel crosslinker. Then the cation was introduced as a second crosslinker to create a double crosslinked network. The method leads to the precise regulation of the hydrogel characters, including the biodegradation rate and the controlled release rate of the drug. As a result, the optimized hydrogels facilitated the live-cell infiltration in vitro and boosted the tissue regeneration of diabetic wounds in vivo. The results indicated that the addition of the microgel as a new crosslinker created flexibility during the construction of the alginate hydrogel, adapting for diverse applications during diabetic-induced wound therapy.
海藻酸盐水凝胶在糖尿病伤口愈合方面受到了广泛关注。然而，离子交联方法的可调性有限，无法针对不同的伤口条件来精细地管理物理性能。我们通过使用微凝胶颗粒（由锌离子制成，并通过羧甲基壳聚糖和醛基透明质酸的复合物进行配位）作为一种新型交联剂来解决这个问题。然后引入阳离子作为第二种交联剂，以创建双交联网络。该方法可以精确调节水凝胶的特性，包括药物的降解速率和控制释放速率。结果表明，优化后的水凝胶促进了活细胞在体外的渗透，并促进了糖尿病伤口的组织再生。结果表明，添加微凝胶作为新的交联剂在海藻酸盐水凝胶的构建过程中增加了灵活性，适应了糖尿病诱导的伤口治疗中的各种应用。
