环状 RNA 在肿瘤放射抵抗中的作用。

CircRNAs in Tumor Radioresistance.

机构信息

Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, China.

Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and School of Public Health, Southern Medical University, Guangzhou 510000, China.

出版信息

Biomolecules. 2022 Oct 28;12(11):1586. doi: 10.3390/biom12111586.

DOI:10.3390/biom12111586

PMID:36358938

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9687855/

Abstract

RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs' leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tumor cells and can be used as biological markers of tumors. In addition, circRNAs can regulate the radiosensitivity of tumors. Here, we list the mechanisms of circRNAs in glioma, nasopharyngeal carcinoma, and non-small cell lung cancer; further, these studies also provide new ideas for the purposes of eliminating radioresistance in tumors.

摘要

RNAs (circRNAs) 是内源性的非编码 RNA，来源于存在于多种物种中的宿主基因，可参与各种疾病的进展。circRNAs 的主要作用是充当 RNA 海绵。近年来，已经发现了 circRNAs 的其他作用，例如调节转录和翻译、调节宿主基因，甚至被翻译成蛋白质。由于一些肿瘤细胞不再对放射敏感，因此肿瘤放射抗性已成为治疗肿瘤的挑战。近年来，circRNAs 在肿瘤细胞中差异表达，可作为肿瘤的生物标志物。此外，circRNAs 可以调节肿瘤的放射敏感性。在这里，我们列出了 circRNAs 在神经胶质瘤、鼻咽癌和非小细胞肺癌中的作用机制；此外，这些研究也为消除肿瘤中的放射抗性提供了新的思路。