Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China.
Shanghai Clinical Medical Center of Hearing Medicine, Shanghai 200031, China.
Biomolecules. 2022 Nov 3;12(11):1625. doi: 10.3390/biom12111625.
Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I/R in different organs, as well as potential treatment strategies targeting it to combat I/R injury.
缺血再灌注（I/R）损伤在心肌梗死、中风或急性肾损伤患者中并不常见，但会导致细胞死亡和器官功能障碍。先前的研究表明，在 I/R 损伤过程中会发生不同类型的细胞死亡，包括细胞凋亡、坏死和自噬。细胞焦亡，其特征为细胞膜孔形成、促炎细胞因子释放和细胞破裂，与细胞凋亡和坏死不同，已被发现与 I/R 损伤密切相关。因此，针对细胞焦亡的信号通路和关键调节剂可能有利于治疗目前还远远不够的 I/R 损伤。这篇综述总结了细胞焦亡及其与不同器官 I/R 的关系的最新状况，以及针对其的潜在治疗策略以对抗 I/R 损伤。
