Division of Cardiology, Departments of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
GI Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Biomolecules. 2022 Nov 3;12(11):1627. doi: 10.3390/biom12111627.
Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles in the pathogenesis of cancer, chronic inflammatory diseases, and many autoimmune disorders. The accumulation and activation of MDSCs can be regulated by tumor necrosis factor α (TNF-α). In this review, we summarize the roles played by TNF-α in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs, and discuss the potential therapeutic effects of TNF-α upon these cells in tumor growth and some inflammatory disorders.
髓源性抑制细胞（MDSCs）是一群具有免疫抑制功能的未成熟和异质性的髓系细胞。MDSCs 在癌症、慢性炎症性疾病和许多自身免疫性疾病的发病机制中发挥重要作用。MDSCs 的积累和激活可受肿瘤坏死因子-α（TNF-α）调节。在这篇综述中，我们总结了 TNF-α在 MDSCs 的募集、免疫抑制功能和趋化作用中的作用，并讨论了 TNF-α 对肿瘤生长和某些炎症性疾病中这些细胞的潜在治疗效果。
