Migheli Rossana, Virdis Patrizia, Galleri Grazia, Arru Caterina, Lostia Giada, Coradduzza Donatella, Muroni Maria Rosaria, Pintore Giorgio, Podda Luigi, Fozza Claudio, De Miglio Maria Rosaria
Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Biomedicines. 2022 Oct 28;10(11):2739. doi: 10.3390/biomedicines10112739.
Cancer is a complex disease including approximately 200 different entities that can potentially affect all body tissues. Among the conventional treatments, radiotherapy and chemotherapy are most often applied to different types of cancers. Despite substantial advances in the development of innovative antineoplastic drugs, cancer remains one of the most significant causes of death, worldwide. The principal pitfall of successful cancer treatment is the intrinsic or acquired resistance to therapeutic agents. The development of more effective or synergistic therapeutic approaches to improve patient outcomes and minimize toxicity has become an urgent issue. is widely distributed throughout Europe, Africa, and Asia. Used as a medicinal plant in different countries, has been characterized for its complex chemical composition in order to identify the bioactive compounds responsible for its biological activities, including anticancer effects. Sesquiterpene lactones (SLs) are natural, biologically active products that have attracted considerable attention due to their biological activities. SLs are alkylating agents that form covalent adducts with free cysteine residues within enzymes and key proteins favoring cancer cell cytotoxicity. They are effective inducers of apoptosis in several cancer cell types through different molecular mechanisms. This review focuses on recent advances in the cytotoxic effects of and SLs in the treatment of neoplastic diseases, with a special emphasis on their proapoptotic molecular mechanisms.
癌症是一种复杂的疾病，包括约200种不同的类型，可能影响身体所有组织。在传统治疗方法中，放疗和化疗最常用于不同类型的癌症。尽管创新抗肿瘤药物的研发取得了重大进展，但癌症仍是全球最重要的死亡原因之一。成功治疗癌症的主要障碍是对治疗药物的内在或获得性耐药性。开发更有效或协同的治疗方法以改善患者预后并将毒性降至最低已成为一个紧迫问题。[此处缺少具体植物名称]广泛分布于欧洲、非洲和亚洲。在不同国家被用作药用植物，[此处缺少具体植物名称]因其复杂的化学成分而被表征，以确定负责其生物活性（包括抗癌作用）的生物活性化合物。倍半萜内酯（SLs）是天然的生物活性产物，因其生物活性而备受关注。SLs是烷基化剂，可与酶和关键蛋白中的游离半胱氨酸残基形成共价加合物，有利于癌细胞的细胞毒性。它们通过不同的分子机制在几种癌细胞类型中是有效的凋亡诱导剂。本综述重点关注[此处缺少具体植物名称]和SLs在肿瘤疾病治疗中的细胞毒性作用的最新进展，特别强调它们的促凋亡分子机制。
