粘毛旋覆花中的倍半萜内酯inuviscolide对促炎酶的抑制作用。
Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa.
作者信息
Máñez Salvador, Hernández Victoriano, Giner Rosa-María, Ríos José-Luis, Recio María Del Carmen
机构信息
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avinguda Vicent Andrés Estellés s/n, 46100 Burjassot, Spain.
出版信息
Fitoterapia. 2007 Jun;78(4):329-31. doi: 10.1016/j.fitote.2007.03.005. Epub 2007 Apr 11.
This work concerns the pharmacological activity of inuviscolide, a sesquiterpenoid from Inula viscosa. It exerts inhibitory effects on elastase, cyclooxygenase 1 and secretory phospholipase A(2). Furthermore, it reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate.
这项研究涉及来自粘毛旋覆花的倍半萜烯类化合物inuviscolide的药理活性。它对弹性蛋白酶、环氧化酶1和分泌型磷脂酶A2具有抑制作用。此外，在通过重复涂抹12-O-十四烷酰佛波醇-13-乙酸酯诱导的小鼠皮炎模型中，它能减少皮肤白细胞浸润。
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