de Bengy Anne-France, Decorps Johanna, Martin Lisa S, Pagnon Aurélie, Chevalier Fabien P, Sigaudo-Roussel Dominique, Fromy Bérengère
AF BioCell, 59 Avenue du Point du Jour, 69005 Lyon, France.
CNRS, LBTI UMR5305, Univ. Lyon, Université Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 7, 69367 Lyon, France.
Biomedicines. 2022 Nov 10;10(11):2887. doi: 10.3390/biomedicines10112887.
Many changes characterize skin aging, and the resulting dysfunctions still constitute a real challenge for our society. The aim of this study was to compare the skin aging of two rat strains, Wistar and Brown Norway (BN), considered as "poorly aging" and "healthy aging" models, respectively, and to assess the effect of alpha-lipoic acid (LPA), especially on skin microcirculation. To this purpose, various skin characteristics were studied at 6, 12, and 24 months and compared to the results of LPA treatment performed at 12 or 24 months. Skin aging occurred in both strains, but we showed an early occurrence of different age-related disorders in the Wistar strain compared to BN strain, especially regarding weight gain, glycemia dysregulation, basal skin perfusion, endothelial function, and skin resistance to low pressure. LPA treatment tended to improve skin resistance to low pressure in BN but not in Wistar despite the improvement of basal skin perfusion, endothelial function, and skin sensory sensitivity. Overall, this study confirmed the healthier aging of BN compared to Wistar strain and the positive effect of LPA on both general state and skin microcirculation.
皮肤老化有许多特征，由此产生的功能障碍仍然是我们社会面临的一项现实挑战。本研究的目的是比较两种大鼠品系（Wistar和Brown Norway，分别被视为“老化较差”和“健康老化”模型）的皮肤老化情况，并评估α-硫辛酸（LPA）的作用，特别是对皮肤微循环的影响。为此，在6个月、12个月和24个月时研究了各种皮肤特征，并与在12个月或24个月时进行LPA治疗的结果进行比较。两种品系的大鼠均出现了皮肤老化，但我们发现，与BN品系相比，Wistar品系更早出现了与年龄相关的不同病症，尤其是在体重增加、血糖调节异常、基础皮肤灌注、内皮功能以及皮肤对低压的耐受性方面。尽管基础皮肤灌注、内皮功能和皮肤感觉敏感性有所改善，但LPA治疗倾向于改善BN品系大鼠皮肤对低压的耐受性，而对Wistar品系大鼠则无此作用。总体而言，本研究证实了与Wistar品系相比，BN品系的老化更为健康，以及LPA对整体状态和皮肤微循环具有积极作用。
