Argirò Alessia, Del Franco Annamaria, Mazzoni Carlotta, Allinovi Marco, Tomberli Alessia, Tarquini Roberto, Di Mario Carlo, Perfetto Federico, Cappelli Francesco, Zampieri Mattia
Tuscan Regional Amyloidosis Centre, Careggi University Hospital, 50134 Florence, Italy.
Department of Internal Medicine I, San Giuseppe Hospital, 50053 Empoli, Italy.
Biomedicines. 2022 Nov 10;10(11):2888. doi: 10.3390/biomedicines10112888.
Cardiac amyloidosis (CA), caused by the deposition of insoluble amyloid fibrils, impairs different cardiac structures, altering not only left ventricle (LV) systo-diastolic function but also atrial function and the conduction system. The consequences of the involvement of the cardiac electrical system deserve more attention, as well as the study of the underlying molecular mechanisms. This is an issue of considerable interest, given the conflicting data on the effectiveness of conventional antiarrhythmic strategies. Therefore, this review aims at summarizing the arrhythmic burden related to CA and the available evidence on antiarrhythmic treatment in this population.
心脏淀粉样变性（CA）由不溶性淀粉样纤维沉积引起，会损害不同的心脏结构，不仅改变左心室（LV）的收缩 - 舒张功能，还会影响心房功能和传导系统。心脏电系统受累的后果值得更多关注，其潜在分子机制的研究也同样如此。鉴于传统抗心律失常策略有效性的数据相互矛盾，这是一个备受关注的问题。因此，本综述旨在总结与CA相关的心律失常负担以及该人群抗心律失常治疗的现有证据。
