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转座元件作为真核生物基因组中新的重复 DNA 的来源。

Transposable Elements as a Source of Novel Repetitive DNA in the Eukaryote Genome.

机构信息

Departamento de Genética, Programa de Pós-Graduação em Genética, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, PR, Brazil.

Departamento de Genética, Laboratorio de Citogenética Evolutiva e Conservação Animal, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, PR, Brazil.

出版信息

Cells. 2022 Oct 26;11(21):3373. doi: 10.3390/cells11213373.

Abstract

The impact of transposable elements (TEs) on the evolution of the eukaryote genome has been observed in a number of biological processes, such as the recruitment of the host's gene expression network or the rearrangement of genome structure. However, TEs may also provide a substrate for the emergence of novel repetitive elements, which contribute to the generation of new genomic components during the course of the evolutionary process. In this review, we examine published descriptions of TEs that give rise to tandem sequences in an attempt to comprehend the relationship between TEs and the emergence of de novo satellite DNA families in eukaryotic organisms. We evaluated the intragenomic behavior of the TEs, the role of their molecular structure, and the chromosomal distribution of the paralogous copies that generate arrays of repeats as a substrate for the emergence of new repetitive elements in the genome. We highlight the involvement and importance of TEs in the eukaryote genome and its remodeling processes.

摘要

转座元件 (TEs) 对真核生物基因组进化的影响在许多生物学过程中都有观察到,例如宿主基因表达网络的招募或基因组结构的重排。然而,TEs 也可能为新的重复元件的出现提供底物,这些元件有助于在进化过程中产生新的基因组成分。在这篇综述中,我们检查了描述 TEs 产生串联序列的已发表描述,试图理解 TEs 与真核生物中新的卫星 DNA 家族的出现之间的关系。我们评估了 TEs 的基因组内行为、其分子结构的作用以及产生重复序列阵列的同源拷贝的染色体分布,作为基因组中新重复元件出现的底物。我们强调了 TEs 在真核生物基因组及其重塑过程中的参与和重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/349a/9659126/4c9b7b7d7d8b/cells-11-03373-g001.jpg

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