神经疾病中的 DNA 甲基化。
The DNA Methylation in Neurological Diseases.
机构信息
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1971653313, Iran.
The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
出版信息
Cells. 2022 Oct 31;11(21):3439. doi: 10.3390/cells11213439.
DNA methylation is critical for the normal development and functioning of the human brain, such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal reparation, learning, and memory. Despite the physical stability of DNA and methylated DNA compared to other epigenetic modifications, some DNA methylation-based biomarkers have translated into clinical practice. Increasing reports indicate a strong association between DNA methylation profiles and various clinical outcomes in neurological diseases, making DNA methylation profiles valuable as novel clinical markers. In this review, we aim to discuss the latest evidence concerning DNA methylation alterations in the development of neurodegenerative, neurodevelopmental, and neuropsychiatric diseases. We also highlighted the relationship of DNA methylation alterations with the disease progression and outcome in many neurological diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and autism.
DNA 甲基化对于人类大脑的正常发育和功能至关重要，例如神经干细胞的增殖和分化、突触可塑性、神经元修复、学习和记忆。尽管与其他表观遗传修饰相比，DNA 和甲基化 DNA 具有物理稳定性，但一些基于 DNA 甲基化的生物标志物已转化为临床实践。越来越多的报告表明，DNA 甲基化谱与神经疾病中的各种临床结果之间存在很强的关联，这使得 DNA 甲基化谱成为有价值的新型临床标志物。在这篇综述中，我们旨在讨论有关神经退行性、神经发育和神经精神疾病发展过程中 DNA 甲基化改变的最新证据。我们还强调了 DNA 甲基化改变与许多神经疾病（如阿尔茨海默病、帕金森病、肌萎缩侧索硬化症、额颞叶痴呆和自闭症）的疾病进展和结果之间的关系。
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