Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55902, USA.
Cells. 2022 Nov 2;11(21):3469. doi: 10.3390/cells11213469.
The infusion of autograft immune effector cells directly impacts the clinical outcomes of patients treated with autologous peripheral blood hematopoietic stem cell transplantation, suggesting the possibility of an autologous graft-versus tumor cells. Furthermore, the early recovery of immune effector cells also affects survival post-autologous peripheral blood hematopoietic stem cell transplantation. Natural killer cells are among the immune effector cells reported to be collected, infused, and recovered early post-autologous peripheral blood hematopoietic stem cell transplantation. In this review, I attempt to give an update on the role of natural killer cells regarding improving survival outcomes on patients treated with autologous peripheral blood hematopoietic stem cell transplantation.
自体免疫效应细胞输注直接影响接受自体外周血造血干细胞移植治疗的患者的临床结局，提示存在自体移植物抗肿瘤细胞的可能性。此外，免疫效应细胞的早期恢复也会影响自体外周血造血干细胞移植后的生存。据报道，在采集、输注和自体外周血造血干细胞移植后早期恢复的免疫效应细胞中，包括自然杀伤细胞。在这篇综述中，我试图介绍自然杀伤细胞在改善自体外周血造血干细胞移植治疗患者的生存结果方面的作用的最新进展。
