Dracott B N, Wedderburn N, Doenhoff M J
Immunology. 1978 Apr;34(4):679-87.
Splenic immune responses having varying dependence on accessory cell co-operation have been studied after infection of mice with Friend virus. Infection has no effect on cell proliferation or antibody production in cultures stimulated with E. coli lipopolysaccharide. The response in vivo to type III pneumococcal polysaccharide is depressed only moderately. The response to sheep red blood cells is depressed severely both in vivo and in vitro. Depression in vitro is greatly reduced by co-stimulation with E. coli lipopolysaccharide. Depletion of potential suppressor lymphocyte populations by irradiation or adult thymectomy does not ameliorate depression of responses to sheep red blood cells or pneumococcal polysaccharide. Responses after adult thymectomy plus irradiation are not affected by the virus. Although it is known that macrophage and helper T-lymphocyte co-operation are not themselves impaired by infection, these results suggest that there is a direct relationship between severity of immune depression and dependence on co-operation. Implications for the action of the virus are discussed.
在用弗氏病毒感染小鼠后，对依赖辅助细胞协同作用程度各异的脾脏免疫反应进行了研究。感染对用大肠杆菌脂多糖刺激的培养物中的细胞增殖或抗体产生没有影响。体内对Ⅲ型肺炎球菌多糖的反应仅略有降低。对绵羊红细胞的反应在体内和体外均严重降低。通过与大肠杆菌脂多糖共同刺激，体外的抑制作用大大降低。通过照射或成年胸腺切除耗尽潜在的抑制性淋巴细胞群体并不能改善对绵羊红细胞或肺炎球菌多糖反应的抑制。成年胸腺切除加照射后的反应不受病毒影响。虽然已知巨噬细胞和辅助性T淋巴细胞的协同作用本身不会因感染而受损，但这些结果表明免疫抑制的严重程度与对协同作用的依赖性之间存在直接关系。讨论了该病毒作用的相关影响。
