Brzezinski Piotr, Zonda Gabriela Ildiko, Hincu Maura Adelina, Vasilache Ingrid-Andrada, Chiriac Anca, Ciuhodaru Madalina Irina, Borowska Katarzyna, Paduraru Luminita
Department of Physiotherapy and Medical Emergency, Faculty of Health Sciences, Pomeranian Academy Slupsk, 76-200 Slupsk, Poland.
Department of Dermatology, Provincial Specialist Hospital in Slupsk, 76-270 Ustka, Poland.
Children (Basel). 2022 Oct 23;9(11):1612. doi: 10.3390/children9111612.
(1) Background: Isotretinoin (ISO) is a systemic retinoid known for its teratogenic effects on embryos and fetuses. The aim of this study was to compare the pregnancy outcomes of women who were exposed to isotretinoin with those of women without such exposure from a teratogenic point of view. (2) Methods: A total of 1459 female patients from three clinical hospitals in Poland and Romania, segregated into two groups depending on their ISO exposure, were evaluated between January and December 2019. Medical records were screened to identify the pregnancy outcomes and congenital malformation rates. (3) Results: The congenital malformation rate for the exposed group was 1.2% (four cases), and no specific signs of Accutane embryopathy were identified. Women from the unexposed group were more likely to deliver preterm and through cesarean deliveries and had a higher rate of newborn congenital malformations as compared to women from the exposed group. (4) Conclusions: Even though we could not find a significant association between ISO exposure and teratogenic effects in newborns, effective contraceptive measures are key to preventing unfavorable pregnancy outcomes.
(1) 背景：异维A酸（ISO）是一种全身性类视黄醇，因其对胚胎和胎儿具有致畸作用而闻名。本研究的目的是从致畸角度比较接触异维A酸的女性与未接触异维A酸的女性的妊娠结局。(2) 方法：2019年1月至12月期间，对来自波兰和罗马尼亚三家临床医院的1459名女性患者进行了评估，根据她们接触异维A酸的情况分为两组。筛查医疗记录以确定妊娠结局和先天性畸形率。(3) 结果：暴露组的先天性畸形率为1.2%（4例），未发现异维A酸胚胎病的特定体征。与暴露组女性相比，未暴露组女性更有可能早产并通过剖宫产分娩，新生儿先天性畸形率更高。(4) 结论：尽管我们未发现接触异维A酸与新生儿致畸作用之间存在显著关联，但有效的避孕措施是预防不良妊娠结局的关键。
