CBIOS-Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal.
Health Sciences Ph.D. Program, University of Alcalá, Carretera Madrid-Barcelona, Km 33.100, 28805 Alcalá de Henares, Spain.
Int J Environ Res Public Health. 2022 Oct 23;19(21):13791. doi: 10.3390/ijerph192113791.
The human gastrointestinal (GI) tract is a dynamic system influenced by various environmental factors, including diet and exposure to ingested probiotics, and prone to various functional impairments. These impairments are mostly related to any combination of motility alterations, visceral hypersensitivity, and changes in the mucosa, immune function, and intestinal microbiota. Intestinal microbial imbalance and immunological dysfunction have been linked to several chronic inflammatory disease states, including atopic dermatitis (AD). Disruption of the intestinal microbial balance, known as gut dysbiosis, has been demonstrated to negatively impact skin function by increasing the intestinal permeability. Consequently, the gut-skin axis may be receptive to modulation via dietary modification, namely, via ingestion of probiotics, thus representing interesting potential as an AD therapy. Kefir is an ancient probiotic food that has been demonstrated to positively impact the general condition of the digestive system, including the intestinal microbiota. However, the literature is still scarce on the impact on the gut-skin relationship of a diet containing kefir. This study, continuing research in our group, aimed to evaluate the impact of kefir intake on GI symptoms in healthy and AD skin subjects. Results showed a significant improvement in GI status, namely, in functional constipation, abdominal pain intensity, and abdominal distension, thus supporting the hypothesis that kefir intake is positively associated with improvement in GI status. The existence of a relationship between the improvement in skin parameters and the improvement in GI status after kefir consumption was established, thus reinforcing the role of homemade kefir as a potential modulator of the gut-skin axis in both healthy and atopic individuals.
人类胃肠道（GI）是一个受多种环境因素影响的动态系统，包括饮食和摄入的益生菌，并且容易受到各种功能障碍的影响。这些损伤主要与运动改变、内脏敏感性、黏膜变化、免疫功能和肠道微生物群的任何组合有关。肠道微生物失衡和免疫功能障碍与几种慢性炎症性疾病状态有关，包括特应性皮炎（AD）。肠道微生物平衡的破坏，称为肠道菌群失调，已被证明通过增加肠道通透性对皮肤功能产生负面影响。因此，肠道-皮肤轴可能容易受到饮食改变的调节，即通过摄入益生菌，因此作为 AD 治疗具有潜在的吸引力。开菲尔是一种古老的益生菌食品，已被证明对消化系统的一般状况，包括肠道微生物群，有积极的影响。然而，关于含开菲尔的饮食对肠道-皮肤关系的影响的文献仍然很少。本研究是我们小组的延续性研究，旨在评估摄入开菲尔对健康和 AD 皮肤受试者的胃肠道症状的影响。结果显示 GI 状况显著改善，即功能性便秘、腹痛强度和腹胀，这支持了摄入开菲尔与改善 GI 状况相关的假设。在开菲尔消费后，皮肤参数的改善与 GI 状况的改善之间存在关系，从而强化了自制开菲尔作为健康和特应性个体肠道-皮肤轴潜在调节剂的作用。
