Department of Liberal Arts and Science, Suwon Women's University, Onjeong Street 72, Gweonseon-gu, Suwon-si 16632, Korea.
Human IT Solution, Gogum Building 1F, 2F, Banpo-daero, 55, Seocho-gu, Seoul 06670, Korea.
Int J Environ Res Public Health. 2022 Oct 31;19(21):14223. doi: 10.3390/ijerph192114223.
While dietary polyphenols supplements can improve endothelial function and blood flow to exercise, the effects of chronic supplementation with grape seed extract (GSE) containing a high dose of polyphenols on endurance performance are not known. Accordingly, in 12 elite athletes, we compared the effects of both GSE and placebo (PL) on submaximal VO, time to exhaustion performance, and endothelial function during progressive cycling exercise for 14 days. Endothelial function was evaluated from the brachial artery via flow-mediated dilation (FMD). Compared to PL, GSE decreased submaximal VO at 80% and 120% of VO and increased the time to exhaustion ( < 0.05). GSE also resulted in FMD-induced increase in brachial artery diameter (14.4 ± 5.2% vs. 17.6 ± 4.5%, = 0.035). We demonstrated that chronic supplementation with GSE improved endurance performance and these effects may partially be due to vasodilation in active skeletal muscle mediated by enhanced endothelial function. Thus, our results suggest that GSE appears to be an ergogenic nutraceutical that can improve exercise performance in elite athletes.
虽然饮食中的多酚补充剂可以改善内皮功能和血流到运动，但长期补充含有高剂量多酚的葡萄籽提取物（GSE）对耐力表现的影响尚不清楚。因此，在 12 名精英运动员中，我们比较了 GSE 和安慰剂（PL）对渐进性自行车运动 14 天期间的亚最大 VO 、力竭时间表现和内皮功能的影响。通过血流介导的扩张（FMD）从肱动脉评估内皮功能。与 PL 相比，GSE 降低了 80%和 120% VO 的亚最大 VO ，并增加了力竭时间（<0.05）。GSE 还导致肱动脉直径的 FMD 诱导增加（14.4±5.2%对 17.6±4.5%，=0.035）。我们证明，长期补充 GSE 可提高耐力表现，这些作用可能部分归因于通过增强内皮功能介导的活性骨骼肌中的血管扩张。因此，我们的结果表明，GSE 似乎是一种具有生肌作用的营养保健品，可以提高精英运动员的运动表现。
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