N-6-异戊烯基腺嘌呤在肿瘤细胞生长中的作用。
The role of N-6-isopentenyl adenine in tumor cell growth.
作者信息
Adair W L, Brennan S L
出版信息
Biochem Biophys Res Commun. 1986 May 29;137(1):208-14. doi: 10.1016/0006-291x(86)91197-6.
When cell extracts from Ehrlich ascites tumor cells were assayed for isopentenyl adenine content and correlation with cell growth stage by radioimmunoassay, concentrations of low statistical significance were obtained. High performance liquid chromatographic analysis of cell extracts showed undetectable levels of isopentenyl adenine or 8-hydroxy-isopentenyl adenine, a known metabolite. Thus these substances do not seem to be required for cell division in Ehrlich ascites tumor cells.
当通过放射免疫测定法检测艾氏腹水瘤细胞的细胞提取物中的异戊烯基腺嘌呤含量及其与细胞生长阶段的相关性时，得到的浓度具有较低的统计学意义。对细胞提取物进行的高效液相色谱分析显示，未检测到异戊烯基腺嘌呤或8-羟基异戊烯基腺嘌呤（一种已知的代谢产物）的水平。因此，这些物质似乎并非艾氏腹水瘤细胞进行细胞分裂所必需的。
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