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卵巢癌中CCAAT/增强子结合蛋白家族的综合分析

Comprehensive Analysis of CCAAT/Enhancer Binding Protein Family in Ovarian Cancer.

作者信息

Tan Jiahong, Wang Daoqi, Dong Wei, Nian Lei, Zhang Fen, Zhao Han, Zhang Jie, Feng Yun

机构信息

Department of Obstetrics and Gynecology, National Key Clinical Specialty of Gynecology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.

Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.

出版信息

Cancer Inform. 2024 Sep 4;23:11769351241275877. doi: 10.1177/11769351241275877. eCollection 2024.

DOI:10.1177/11769351241275877
PMID:39238655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11375656/
Abstract

BACKGROUND

Ovarian cancer has brought serious threats to female health. CCAAT/enhancer binding proteins (C/EBPs) are key transcription factors involved in ovarian cancer. Therefore, comprehensive profiling C/EBPs in ovarian cancer is needed.

METHODS

A comprehensive analysis concerning C/EBPs in ovarian cancer was performed. Firstly, detailed expression of C/EBP family members was integrally retrieved and then confirmed using immunohistochemistry. The regulatory effects and transcription regulatory functions of C/EBPs were studied by using regulatory network analysis and enrichment analysis. Using survival analysis, receiver operating characteristic curve analysis, and target-disease association analysis, the predictive prognostic value of C/EBPs on survival and drug responsiveness was systematically evaluated. The effects of C/EBPs on tumor immune infiltration were also assessed.

RESULTS

Ovarian cancer tissues expressed increased CEBPA, CEBPB, and CEBPG but decreased CEBPD when compared with normal control tissues. The overall alteration frequency of C/EBPs in ovarian cancer was approaching 30%. C/EBP family members formed a reciprocal regulatory network involving carcinogenesis and had pivotal transcription regulatory functions. C/EBPs could affect survival of ovarian cancer and correlated with poor survival outcomes (OS: HR = 1.40, P = .0053 and PFS: HR = 1.41, P = .0036). Besides, expression of CEBPA, CEBPB, CEBPD, and CEBPE could predict platinum and taxane responsiveness of ovarian cancer. C/EBPs also affected immune infiltration of ovarian cancer.

CONCLUSIONS

C/EBPs were closely involved in ovarian cancer and exerted multiple biological functions. C/EBPs could be exploited as prognostic and predictive biomarkers in ovarian cancer.

摘要

背景

卵巢癌给女性健康带来了严重威胁。CCAAT/增强子结合蛋白（C/EBPs）是参与卵巢癌的关键转录因子。因此，需要全面分析卵巢癌中的C/EBPs。

方法

对卵巢癌中的C/EBPs进行了全面分析。首先，完整检索了C/EBP家族成员的详细表达情况，然后通过免疫组织化学进行确认。利用调控网络分析和富集分析研究了C/EBPs的调控作用和转录调控功能。通过生存分析、受试者工作特征曲线分析和靶疾病关联分析，系统评估了C/EBPs对生存和药物反应性的预测预后价值。还评估了C/EBPs对肿瘤免疫浸润的影响。

结果

与正常对照组织相比，卵巢癌组织中CEBPA、CEBPB和CEBPG表达增加，而CEBPD表达降低。卵巢癌中C/EBPs的总体改变频率接近30%。C/EBP家族成员形成了一个涉及致癌作用的相互调控网络，并具有关键的转录调控功能。C/EBPs可影响卵巢癌的生存，并与不良生存结果相关（总生存期：HR = 1.40，P = 0.0053；无进展生存期：HR = 1.41，P = 0.0036）。此外，CEBPA、CEBPB、CEBPD和CEBPE的表达可预测卵巢癌对铂类和紫杉烷类药物的反应性。C/EBPs还影响卵巢癌的免疫浸润。

结论

C/EBPs密切参与卵巢癌并发挥多种生物学功能。C/EBPs可作为卵巢癌的预后和预测生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/13d801c22f99/10.1177_11769351241275877-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/fe04513275e7/10.1177_11769351241275877-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/4ec06ccf3c0d/10.1177_11769351241275877-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/f964d159de47/10.1177_11769351241275877-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/f5f09dd419e8/10.1177_11769351241275877-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/76d33fa3add6/10.1177_11769351241275877-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/13d801c22f99/10.1177_11769351241275877-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/fe04513275e7/10.1177_11769351241275877-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/4ec06ccf3c0d/10.1177_11769351241275877-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/f964d159de47/10.1177_11769351241275877-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/f5f09dd419e8/10.1177_11769351241275877-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/76d33fa3add6/10.1177_11769351241275877-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/11375656/13d801c22f99/10.1177_11769351241275877-fig6.jpg

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