Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Int J Mol Sci. 2022 Oct 29;23(21):13188. doi: 10.3390/ijms232113188.
Epilepsy is a brain disorder characterized by recurrent epileptic seizures and neurobiological, physiological, mood, and cognitive consequences. In the last decade, the beneficial effects of regular physical exercise have been investigated in patients with neurodegenerative diseases such as epilepsy. However, data on its beneficial effects and underlying mechanisms are still insufficient. The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase. Long-term aerobic training, applied four weeks before SE and eight weeks after SE, elevated the threshold to induce SE and reduced spontaneous motor seizures. The protective effect of this alternative approach on seizure susceptibility resulted in improved memory responses, and alleviated comorbid depression in epileptic rats. The exercised epileptic rats had improved markers of oxidative stress by decreasing lipid peroxidation and increasing the levels of glutathione and activity of superoxide dismutase in the rat hippocampus. Aerobic training managed to ameliorate the neuroinflammation by decreasing the levels of TNF-α and IL-1β in the hippocampus. Our results suggest that regular physical training predisposes the subjects to crucial plastic changes, leading to increased resistance to SE and the development of epileptogenesis.
癫痫是一种以反复癫痫发作和神经生物学、生理学、情绪和认知后果为特征的脑部疾病。在过去的十年中，人们研究了定期进行身体锻炼对癫痫等神经退行性疾病患者的有益影响。然而，关于其有益效果和潜在机制的数据仍然不足。本研究的目的是研究耐力训练在匹罗卡品（Pilo）给药前后的应用对癫痫持续状态（SE）严重程度的影响，以及其与慢性癫痫期癫痫发生有害后果的关系。长期的有氧运动训练，在 SE 前四周和 SE 后八周进行，提高了诱发 SE 的阈值，并减少了自发性运动性发作。这种替代方法对易感性的保护作用导致了记忆反应的改善，并减轻了癫痫大鼠的共病性抑郁。运动性癫痫大鼠通过降低海马中脂质过氧化水平、增加谷胱甘肽水平和超氧化物歧化酶活性，改善了氧化应激标志物。有氧运动通过降低海马中的 TNF-α 和 IL-1β 水平，成功缓解了神经炎症。我们的研究结果表明，有规律的体育锻炼使受试者容易发生重要的可塑性变化，从而提高对 SE 的抵抗力和癫痫发生的发展。
