Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand.
Exercise and Sport Sciences Development and Research Group, Khon Kaen University, Khon Kaen 40002, Thailand.
Int J Mol Sci. 2022 Nov 1;23(21):13336. doi: 10.3390/ijms232113336.
This study investigated the associations between relative telomere length (RTL) and resting metabolic rate (RMR), resting fat oxidation (RFO), and aerobic capacity and whether oxidative stress and inflammation are the underlying mechanisms in sedentary women. We also aimed to determine whether the correlations depend on age and obesity. Sixty-eight normal weight and 66 obese women participated in this study. After adjustment for age, energy expenditure, energy intake, and education level, the RTL of all participants was negatively correlated with absolute RMR (RMRAB) and serum high-sensitivity C-reactive protein (hsCRP) concentration, and positively correlated with maximum oxygen consumption (V˙O2max) (all p < 0.05). After additional adjustment for adiposity indices and fat-free mass (FFM), RTL was positively correlated with plasma vitamin C concentration (p < 0.05). Furthermore, after adjustment for fasting blood glucose concentration, RTL was negatively correlated with age and positively correlated with V˙O2max (mL/kg FFM/min). We found that normal weight women had longer RTL than obese women (p < 0.001). We suggest that RTL is negatively correlated with RMRAB and positively correlated with aerobic capacity, possibly via antioxidant and anti-inflammatory mechanisms. Furthermore, age and obesity influenced the associations. We provide useful information for the management of promotion strategies for health-related physical fitness in women.
本研究旨在探讨相对端粒长度（RTL）与静息代谢率（RMR）、静息脂肪氧化（RFO）和有氧能力之间的关系，以及氧化应激和炎症是否是久坐女性的潜在机制。我们还旨在确定这些相关性是否取决于年龄和肥胖。本研究共纳入 68 名正常体重女性和 66 名肥胖女性。在校正年龄、能量消耗、能量摄入和教育水平后，所有参与者的 RTL 与绝对 RMR（RMRAB）和血清高敏 C 反应蛋白（hsCRP）浓度呈负相关，与最大耗氧量（V˙O2max）呈正相关（均 p < 0.05）。在进一步校正肥胖指数和去脂体重（FFM）后，RTL 与血浆维生素 C 浓度呈正相关（p < 0.05）。此外，在校正空腹血糖浓度后，RTL 与年龄呈负相关，与 V˙O2max 呈正相关（mL/kg FFM/min）。我们发现正常体重女性的 RTL 长于肥胖女性（p < 0.001）。我们认为，RTL 与 RMRAB 呈负相关，与有氧能力呈正相关，这可能是通过抗氧化和抗炎机制实现的。此外，年龄和肥胖会影响这些相关性。我们为管理女性健康相关体适能的促进策略提供了有用的信息。
