Chebotariov Institute of Gerontology NAMS of Ukraine, Kyiv 04114, Ukraine.
Komisarenko Institute of Endocrinology and Metabolism NAMS of Ukraine, Kyiv 04114, Ukraine; Department of Endocrinology, Shupyk National Medical Academy of Postgraduate Education, Kyiv 04112, Ukraine.
Exp Gerontol. 2018 Sep;110:247-252. doi: 10.1016/j.exger.2018.06.027. Epub 2018 Jun 26.
Diabetes-related conditions such as chronic hyperglycemia and related oxidative stress and inflammation were repeatedly associated with accelerated telomere shortening in epidemiological studies, although some findings are inconsistent. In present study, we aimed to assess the impact of disturbances in glucose metabolism on association between age and leukocyte telomere length (LTL) in the Ukrainian population. The study was conducted on the 119 adult subjects aged between 43 and 87 years residing in the Kyiv region, Ukraine. LTL was determined by a quantitative PCR-based method. LTL was negatively correlated with the measure of abdominal obesity such as waist-hip ratio, as well as with both fasting plasma glucose (FPG) and two-hour post-load glucose (2hPG) levels. Consistently with previous studies, a significant negative association between LTL and age was observed in individuals with normal (<5.6 mmol/L) FPG levels. Unexpectedly, however, no association was found in subjects with impaired glucose metabolism assessed by abnormal FPG or/and 2hPG levels. No association between LTL and age was observed in a logistic regression model; the association between LTL and age became significant after adjusting for FPG level. In the FPG-adjusted model, 1.6-time lower odds to have long telomere length were indicated for each 10 years increase in age. We hypothesize that the attenuation of association between LTL and age in hyperglycemic persons can likely be attributed to the interaction of multidirectional processes determining this relationship.
在流行病学研究中，糖尿病相关疾病（如慢性高血糖和相关的氧化应激和炎症）与端粒缩短加速有关，尽管一些研究结果不一致。在本研究中，我们旨在评估葡萄糖代谢紊乱对乌克兰人群中年龄与白细胞端粒长度（LTL）之间关联的影响。该研究在乌克兰基辅地区的 119 名年龄在 43 至 87 岁之间的成年受试者中进行。LTL 通过基于定量 PCR 的方法确定。LTL 与腹部肥胖的衡量指标（如腰臀比）以及空腹血糖（FPG）和餐后 2 小时血糖（2hPG）水平呈负相关。与之前的研究一致，在 FPG 水平正常（<5.6mmol/L）的个体中，LTL 与年龄呈显著负相关。然而，出乎意料的是，在通过异常 FPG 或/和 2hPG 水平评估的葡萄糖代谢受损的受试者中，未发现 LTL 与年龄之间存在关联。在逻辑回归模型中，LTL 与年龄之间没有关联；在校正 FPG 水平后，LTL 与年龄之间的关联变得显著。在 FPG 校正模型中，年龄每增加 10 岁，端粒较长的可能性就会降低 1.6 倍。我们假设，在高血糖人群中，LTL 与年龄之间关联的减弱可能归因于确定这种关系的多向过程的相互作用。
