Vartolomei Liliana, Schmidinger Manuela, Vartolomei Mihai Dorin, Shariat Shahrokh F
Department of Urology, Medical University of Vienna, 1090 Vienna, Austria.
Institution Organizing University Doctoral Studies I.O.S.U.D, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology from Târgu Mureș, 540139 Târgu Mureș, Romania.
J Clin Med. 2022 Oct 28;11(21):6383. doi: 10.3390/jcm11216383.
(1) Background: The incidence of psychological distress and its impact on renal cell carcinoma (RCC) patients is unclear. Our aim was to analyze the literature regarding the prevalence of psychological distress and its impact on patients with non-metastatic or metastatic RCC; (2) Methods: A systematic search of five databases was performed. Studies were considered eligible if they included patients with RCC, had a prospective or retrospective design, and assessed anxiety, depression, or psychological distress at any time during treatment or follow-up. Exclusion criteria: no treatment for RCC, or not providing data for RCC patients; (3) Results: A total of 15 studies were included. Reported psychological distress was up to 77% and the prevalence of depressive and anxiety symptoms were up to 77.6% and 68.3% in patients with non-metastatic RCC. There was no association of depression with overall survival (OS) in patients with non-metastatic RCC treated by radical nephrectomy; on the contrary, in patients with metastatic disease, depression had an impact on OS. Limitations are related to the quality of the included studies; (4) Conclusions: Patients with RCC reported a high level of psychological distress like other cancer patients. It seems that for patients with localized disease, psychological distress does not impact OS, while it does in those with metastatic disease.
(1) 背景：心理困扰的发生率及其对肾细胞癌（RCC）患者的影响尚不清楚。我们的目的是分析有关心理困扰患病率及其对非转移性或转移性RCC患者影响的文献；(2) 方法：对五个数据库进行了系统检索。如果研究纳入了RCC患者，采用前瞻性或回顾性设计，并在治疗或随访的任何时间评估焦虑、抑郁或心理困扰，则被认为符合纳入标准。排除标准：未对RCC进行治疗，或未提供RCC患者的数据；(3) 结果：共纳入15项研究。报告的心理困扰发生率高达77%，非转移性RCC患者的抑郁和焦虑症状患病率分别高达77.6%和68.3%。在接受根治性肾切除术的非转移性RCC患者中，抑郁与总生存期（OS）无关联；相反，在转移性疾病患者中，抑郁对OS有影响。局限性与纳入研究的质量有关；(4) 结论：与其他癌症患者一样，RCC患者报告的心理困扰程度较高。似乎对于局限性疾病患者，心理困扰不影响OS，而对于转移性疾病患者则有影响。
