de Barbeyrac B, Quentin C, Bébéar C
J Antimicrob Chemother. 1986 May;17 Suppl C:35-9. doi: 10.1093/jac/17.suppl_c.35.
The in-vitro activity of ticarcillin alone and with 4 and 8 mg/l of clavulanic acid, has been studied on 100 strains of Bacteroides (66 Bacteroides fragilis, 13 B. ovatus, 11 B. vulgatus, 6 B. distasonis, 4 B. thetaiotaomicron) by an agar-dilution method and compared to that of latamoxef cefoxitin, cefotaxime, ceftizoxime, ceftriaxone, cefmenoxime, ceftazidime and metronidazole. All the strains tested were susceptible to the combination of ticarcillin-clavulanic acid (MIC less than or equal to 8 mg/l), to metronidazole (MIC less than or equal to 4 mg/l), and to cefoxitin (MIC less than or equal to 32 mg/l). The combination of ticarcillin and clavulanic acid has an activity superior to that of ticarcillin alone. The MIC90 was 32 mg/l for ticarcillin alone, 1 and 0.5 mg/l for ticarcillin combined with 4 and 8 mg/l of clavulanic acid respectively. Against all the tested strains, cefoxitin was the most active of the cephalosporins, followed by latamoxef (3% of all strains with an MIC greater than 32 mg/l), cefotaxime (5%), ceftizoxime (9%), ceftriaxone (13%), cefmenoxime (17%) and ceftazidime (33%). Differences in sensitivity to cephalosporins were observed within species; the B. ovatus was clearly more resistant than B. fragilis and B. vulgatus. In all species, the combination of ticarcillin and clavulanic acid was always highly active, with MICs less than or equal to 0.01-8 mg/l.
采用琼脂稀释法，对100株拟杆菌（66株脆弱拟杆菌、13株卵形拟杆菌、11株普通拟杆菌、6株狄氏拟杆菌、4株多形拟杆菌）研究了替卡西林单独以及与4mg/L和8mg/L克拉维酸联合应用时的体外活性，并与拉氧头孢、头孢西丁、头孢噻肟、头孢唑肟、头孢曲松、头孢甲肟、头孢他啶和甲硝唑进行比较。所有受试菌株对替卡西林-克拉维酸联合制剂（MIC小于或等于8mg/L）、甲硝唑（MIC小于或等于4mg/L）和头孢西丁（MIC小于或等于32mg/L）敏感。替卡西林与克拉维酸联合应用的活性优于单独使用替卡西林。替卡西林单独应用时的MIC90为32mg/L，与4mg/L和8mg/L克拉维酸联合应用时分别为1mg/L和0.5mg/L。对所有受试菌株而言，头孢西丁是头孢菌素类中活性最强的，其次是拉氧头孢（3%的菌株MIC大于32mg/L）、头孢噻肟（5%）、头孢唑肟（9%）、头孢曲松（13%）、头孢甲肟（17%）和头孢他啶（33%）。在不同菌种间观察到对头孢菌素类敏感性的差异；卵形拟杆菌明显比脆弱拟杆菌和普通拟杆菌耐药。在所有菌种中，替卡西林与克拉维酸联合制剂始终具有高活性，MIC小于或等于0.01 - 8mg/L。
