Branger C, Kitzis M, Le Mée J
Pathol Biol (Paris). 1986 Apr;34(4):245-8.
The in vitro activity of ticarcillin in combination with clavulanic acid was tested, by disc diffusion, against 1,380 clinical bacterial isolates and was compared with that of ticarcillin alone. 83.8% of the isolates were susceptible to ticarcillin + clavulanic acid, whereas 56.6% were susceptible to ticarcillin alone. Minimal inhibitory concentrations (MIC) of ticarcillin in the presence of 4 micrograms/ml of clavulanic acid were determined against 157 ticarcillin resistant (MIC greater than 128 micrograms/ml) but ticarcillin + clavulanic acid susceptible strains of Gram negative bacilli and against 20 strains of beta-lactamase producing Staphylococcus aureus. With the addition of clavulanic acid, MICs of ticarcillin were respectively less than or equal to 16 micrograms/ml and less than or equal to 64 micrograms/ml for 50 and 90% of the Gram negative bacilli. All the Staphylococcus aureus were inhibited by concentrations of ticarcillin less than or equal to 1 microgram/ml.
采用纸片扩散法对替卡西林与克拉维酸联合用药的体外活性进行了测试，受试菌株为1380株临床分离菌，并将其与单用替卡西林的情况进行了比较。83.8%的分离菌对替卡西林+克拉维酸敏感，而单用替卡西林时敏感率为56.6%。针对157株对替卡西林耐药（最低抑菌浓度大于128μg/ml）但对替卡西林+克拉维酸敏感的革兰阴性杆菌菌株以及20株产β-内酰胺酶的金黄色葡萄球菌菌株，测定了在存在4μg/ml克拉维酸的情况下替卡西林的最低抑菌浓度（MIC）。加入克拉维酸后，对于50%和90%的革兰阴性杆菌，替卡西林的MIC分别小于或等于16μg/ml和小于或等于64μg/ml。所有金黄色葡萄球菌均被浓度小于或等于1μg/ml的替卡西林所抑制。
