Department of Rehabilitation Medicine, Gil Medical Center, Incheon 21565, Korea.
Department of Human Movement Science, Incheon National University, Incheon 21999, Korea.
Nutrients. 2022 Oct 26;14(21):4501. doi: 10.3390/nu14214501.
Although sarcopenia has been dealt with in several studies, the standardized guidelines for preventing sarcopenia resulting from increased life expectancy are still insufficient. Therefore, this study evaluated the effects of daily resistance exercise and the intake of leucine-rich protein supplements daily for 12 weeks on the body composition and physical function of healthy adults aged >50 years living in Korea. The study analyzed 50 healthy people without medical conditions, who were randomly assigned to two groups (taking either protein powder or placebo powder) twice a day for 12 weeks. All participants performed resistance exercises regularly that could be repeated 8−12 times using a TheraBand for 12 weeks. A total of 41 participants completed the study. When measured via bioimpedance analysis (BIA), body fat mass (kg) and body fat (%) significantly decreased, and lean body mass (LBM) (kg) and skeletal muscle mass (SMM) (kg) significantly increased, in both groups. However, when measured via dual-energy X-ray absorptiometry (DXA), LBM was significantly increased only in the protein powder group. The LBM and SMM change measured via BIA was significantly greater in the protein powder group than in the placebo powder group (LBM: 0.95 ± 0.91 kg in the protein powder group vs. 0.38 ± 1.06 kg in the placebo powder group, p = 0.043; SMM: 0.69 ± 0.58 kg in the protein powder group vs. 0.29 ± 0.65 kg in the placebo powder group, p = 0.039, respectively). In the senior fitness test (SFT), significant functional improvement was found within the two groups, but no significant difference was found between the groups in the degree of improvement. In conclusion, in older people aged >50, to prevent sarcopenia, is more effective to combine resistance exercise and leucine-rich protein supplementation than to simply perform resistance exercise.
虽然已经有几项研究涉及肌少症,但对于因预期寿命延长而导致肌少症的标准化预防指南仍然不足。因此,本研究评估了每天进行阻力运动和摄入富含亮氨酸的蛋白质补充剂 12 周对韩国 50 岁以上健康成年人的身体成分和身体功能的影响。该研究分析了 50 名无健康状况的健康人,他们随机分为两组(每天服用蛋白质粉或安慰剂粉两次),持续 12 周。所有参与者都定期进行阻力运动,使用TheraBand 可以重复 8-12 次,持续 12 周。共有 41 名参与者完成了这项研究。通过生物电阻抗分析(BIA)测量,两组的体脂肪量(kg)和体脂肪率(%)均显著下降,瘦体重(LBM)(kg)和骨骼肌量(SMM)(kg)均显著增加。然而,通过双能 X 射线吸收法(DXA)测量,仅在蛋白质粉组中 LBM 显著增加。通过 BIA 测量的 LBM 和 SMM 变化在蛋白质粉组中显著大于安慰剂粉组(LBM:蛋白质粉组 0.95±0.91kg,安慰剂粉组 0.38±1.06kg,p=0.043;SMM:蛋白质粉组 0.69±0.58kg,安慰剂粉组 0.29±0.65kg,p=0.039)。在高级体能测试(SFT)中,两组的功能均有显著改善,但两组的改善程度无显著差异。总之,在 50 岁以上的老年人中,预防肌少症,结合阻力运动和富含亮氨酸的蛋白质补充比单纯进行阻力运动更有效。