Postgraduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil.
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59056-000, RN, Brazil.
Nutrients. 2022 Nov 2;14(21):4612. doi: 10.3390/nu14214612.
Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of and variants with MS and MS components in non-diabetic Brazilian adolescents. This cross-sectional study included 174 adolescents who were classified as overweight/obese. Three variants and four variants were identified by allelic discrimination. The polymorphisms, rs12794714 (GG genotype) (odds ratio [OR] = 3.54, 95% confidence interval [CI] = 1.24-10.14, = 0.023) and rs10741657 (recessive model-GG genotype) (OR = 3.90, 95%CI = 1.18-12.92, = 0.026) were significantly associated with an increased risk of MS and hyperglycemia, respectively. The AG + GG genotype (dominant model) of the rs2060793 polymorphism was associated with hyperglycemia protection (OR = 0.28, 95%CI = 0.08-0.92, = 0.037). Furthermore, the CC genotype (recessive model) of the rs7975232 polymorphism was significantly associated with a risk of hypertension (OR = 5.91, 95%CI = 1.91-18.32, = 0.002). In conclusion, the rs12794714 polymorphism could be considered a possible new molecular marker for predicting the risk of MS; rs10741657 polymorphism and rs7975232 polymorphism are associated with an increased risk of diabetes and hypertension in adolescents with overweight/obesity.
维生素 D 缺乏与代谢综合征（MS）之间的关联已有报道；然而，潜在的生物学机制仍存在争议。本研究旨在探讨非糖尿病巴西青少年中 和 变异与 MS 及其组分的相关性。这项横断面研究纳入了 174 名超重/肥胖的青少年。通过等位基因鉴别法确定了三个 变异和四个 变异。 多态性 rs12794714（GG 基因型）（比值比 [OR] = 3.54，95%置信区间 [CI] = 1.24-10.14， = 0.023）和 rs10741657（隐性模型-GG 基因型）（OR = 3.90，95%CI = 1.18-12.92， = 0.026）与 MS 和高血糖的风险增加显著相关。 多态性 rs2060793 的 AG + GG 基因型（显性模型）与高血糖保护相关（OR = 0.28，95%CI = 0.08-0.92， = 0.037）。此外， 多态性 rs7975232 的 CC 基因型（隐性模型）与高血压的风险显著相关（OR = 5.91，95%CI = 1.91-18.32， = 0.002）。总之，rs12794714 多态性可作为预测 MS 风险的新分子标志物；rs10741657 多态性和 rs7975232 多态性与超重/肥胖青少年糖尿病和高血压的风险增加相关。
