Association of and Polymorphisms with Metabolic Syndrome Components in Non-Diabetic Brazilian Adolescents.

Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of and variants with MS and MS components in non-diabetic Brazilian adolescents. This cross-sectional study included 174 adolescents who were classified as overweight/obese. Three variants and four variants were identified by allelic discrimination. The polymorphisms, rs12794714 (GG genotype) (odds ratio [OR] = 3.54, 95% confidence interval [CI] = 1.24-10.14, = 0.023) and rs10741657 (recessive model-GG genotype) (OR = 3.90, 95%CI = 1.18-12.92, = 0.026) were significantly associated with an increased risk of MS and hyperglycemia, respectively. The AG + GG genotype (dominant model) of the rs2060793 polymorphism was associated with hyperglycemia protection (OR = 0.28, 95%CI = 0.08-0.92, = 0.037). Furthermore, the CC genotype (recessive model) of the rs7975232 polymorphism was significantly associated with a risk of hypertension (OR = 5.91, 95%CI = 1.91-18.32, = 0.002). In conclusion, the rs12794714 polymorphism could be considered a possible new molecular marker for predicting the risk of MS; rs10741657 polymorphism and rs7975232 polymorphism are associated with an increased risk of diabetes and hypertension in adolescents with overweight/obesity.