Zhang Junfeng, Cao Jiajia, Ye Qing
Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310052, China.
Vaccines (Basel). 2022 Oct 23;10(11):1783. doi: 10.3390/vaccines10111783.
: The COVID-19 pandemic has imposed a challenge on global healthcare and has tremendously impacted everyone's lives. Vaccination is one of the most effective and vital strategies to halt the pandemic. However, new-onset and relapsed kidney diseases have been reported after COVID-19 vaccination. This narrative review was conducted to collect published data and generalize some hypotheses for the pathogenesis of renal side effects of COVID-19 vaccines. : A systematic literature search of articles reporting renal adverse reactions, including in adults and children, in the PubMed and Web of Science databases until August 2022 was performed. : A total of 130 cases reporting a renal adverse reaction following COVID-19 vaccination from 90 articles were included in this review, of which 90 (69%) were new-onset kidney diseases, while 40 (31%) were relapsed kidney diseases. The most frequent renal side effects of COVID-19 vaccination were minimal change disease (52 cases), IgA nephropathy (48 cases), antineutrophil cytoplasmic autoantibody vasculitis (16 cases), and acute interstitial nephritis (12 cases). Other renal side effects occurred at a much lower frequency. Follow-up data were available for 105 patients, and 100 patients (95%) responded to the treatments. : The number of reported cases is far less than the hundreds of millions of vaccinations, and the benefit of COVID-19 vaccination far outweighs its risks. This review will assist healthcare professionals, particularly nephrologists, who should be aware of these side effects and recognize them early and treat them efficiently.
新冠疫情给全球医疗保健带来了挑战，对每个人的生活都产生了巨大影响。接种疫苗是遏制疫情最有效且至关重要的策略之一。然而，新冠疫苗接种后出现了新发和复发的肾脏疾病报告。本叙述性综述旨在收集已发表的数据，并归纳一些关于新冠疫苗肾脏副作用发病机制的假设。：在PubMed和Web of Science数据库中对截至2022年8月报告肾脏不良反应（包括成人和儿童）的文章进行了系统的文献检索。：本综述纳入了90篇文章中总共130例新冠疫苗接种后报告肾脏不良反应的病例，其中90例（69%）为新发肾脏疾病，40例（31%）为复发肾脏疾病。新冠疫苗接种最常见的肾脏副作用是微小病变病（52例）、IgA肾病（48例）、抗中性粒细胞胞浆抗体血管炎（16例）和急性间质性肾炎（12例）。其他肾脏副作用发生频率要低得多。105例患者有随访数据，100例患者（95%）对治疗有反应。：报告的病例数远少于数亿次疫苗接种，新冠疫苗接种的益处远大于风险。本综述将帮助医疗保健专业人员，尤其是肾病学家，他们应了解这些副作用，尽早识别并有效治疗。
