Li Yebei, Rao Meiying, Xu Gaosi
Department of Nephrology, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Donghu District, Nanchang 330006, China.
Department of Blood Transfusion, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Donghu District, Nanchang 330006, China.
Vaccines (Basel). 2022 May 9;10(5):742. doi: 10.3390/vaccines10050742.
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an exceptional setback to the global economy and health. Vaccination is one of the most effective interventions to markedly decrease severe illness and death from COVID-19. In recent years, there have been increasingly more reports of new acute kidney injury (AKI) after COVID-19 vaccination. Podocyte injury, IgA nephropathy, vasculitis, tubulointerstitial injury, and thrombotic microangiopathy appear to be the main pathological phenotypes. Nonetheless, whether the link between the COVID-19 vaccine and acute kidney disease (AKD) is causal or coincidental remains to be verified. Here, we generalize some hypotheses for the emergence of AKD and its pathogenesis in response to certain COVID-19 vaccines. In fact, the enormous benefits of mass vaccination against COVID-19 in preventing COVID-19 morbidity and mortality cannot be denied. The purpose of this review is to assist in the clinical assessment and management of AKD following COVID-19 vaccination.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行给全球经济和健康带来了巨大挫折。接种疫苗是显著降低COVID-19导致的严重疾病和死亡的最有效干预措施之一。近年来，关于COVID-19疫苗接种后新发急性肾损伤（AKI）的报道越来越多。足细胞损伤、IgA肾病、血管炎、肾小管间质损伤和血栓性微血管病似乎是主要的病理表型。尽管如此，COVID-19疫苗与急性肾脏病（AKD）之间的联系是因果关系还是巧合仍有待证实。在此，我们归纳了针对某些COVID-19疫苗出现AKD及其发病机制的一些假说。事实上，大规模接种COVID-19疫苗在预防COVID-19发病和死亡方面的巨大益处不可否认。本综述的目的是协助对COVID-19疫苗接种后AKD的临床评估和管理。
