Płatkowska-Adamska Bernadetta, Bociek Agnieszka, Krupińska Joanna, Kal Magdalena, Biskup Michał, Zarębska-Michaluk Dorota, Odrobina Dominik
Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
Ophthalmology Clinic, Voivodeship Hospital, 25-727 Kielce, Poland.
Vaccines (Basel). 2022 Nov 7;10(11):1878. doi: 10.3390/vaccines10111878.
Evaluation of the activity of the exudative form of age-related macular degeneration (AMD) during anti-vascular endothelial growth factor (anti-VEGF) therapy before and after administration of BNT162b2 (Pfizer/BioNTech) vaccination.
The optical coherence tomography and best corrected visual acuity (BCVA) records of the two previous visits before the first dose of BNT162b2 (first pre-vaccination visit marked as "V-1", the previous pre-vaccination "V-2"), and two subsequent visits after the second dose of vaccination (first visit after the second dose marked as "V1", second visit after the second dose marked as "V2") were collected for 63 eyes of 59 patients.
The difference in the average retinal thickness was observed between the last and each other checkpoint for the aflibercept group and in the overall outcome. The maximum thickness from the inner retinal surface to the inner border of RPE decreased during the observation; differences were observed comparing visits -2 and 1. Subretinal complex thickness decreased during follow-up, and the differences were observed between visits -2 and 2. There were no statistically significant differences in the BCVA and the occurrence of intraretinal cystoid fluid, serous PED, subretinal hyperreflective material, and retinal hemorrhage.
In the present study, the activity of the exudative form of AMD did not deteriorate after the administration of the BNT162b2 vaccine.
在给予BNT162b2（辉瑞/生物科技公司）疫苗前后，评估抗血管内皮生长因子（抗VEGF）治疗期间年龄相关性黄斑变性（AMD）渗出型的活性。
收集了59例患者63只眼在首次注射BNT162b2之前的两次就诊（首次疫苗接种前就诊标记为“V-1”，之前的疫苗接种前“V-2”）以及第二次疫苗接种后的两次就诊（第二次接种后的首次就诊标记为“V1”，第二次接种后的第二次就诊标记为“V2”）的光学相干断层扫描和最佳矫正视力（BCVA）记录。
阿柏西普组以及总体结果中，观察到末次检查点与其他各检查点之间平均视网膜厚度存在差异。在观察期间，从视网膜内表面到视网膜色素上皮（RPE）内边界的最大厚度减小；比较就诊-2和就诊1时观察到差异。随访期间视网膜下复合体厚度减小，就诊-2和就诊2之间观察到差异。BCVA以及视网膜内囊样液、浆液性色素上皮脱离、视网膜下高反射物质和视网膜出血的发生率无统计学显著差异。
在本研究中，给予BNT162b2疫苗后，AMD渗出型的活性未恶化
