Instituto de Patología Vegetal, Centro de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria (IPAVE-CIAP-INTA), Córdoba X5020ICA, Argentina.
Unidad de Fitopatología y Modelización Agrícola (UFYMA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba X5020ICA, Argentina.
Viruses. 2022 Oct 29;14(11):2403. doi: 10.3390/v14112403.
Morbilliviruses are negative-sense single-stranded monosegmented RNA viruses in the family (order ). Morbilliviruses infect diverse mammals including humans, dogs, cats, small ruminants, seals, and cetaceans, which serve as natural hosts. Here, I report the identification and characterization of novel viruses detected in public RNAseq datasets of South American long-haired and olive field mice. The divergent viruses dubbed Ratón oliváceo morbillivirus (RoMV) detected in renal samples from mice collected from Chile and Argentina are characterized by an unusually large genome including long intergenic regions and the presence of an accessory protein between the F and H genes redounding in a genome architecture consisting in 3'-N-P/V/C-M-F-hp-H-L-5'. Structural and functional annotation, genetic distance, and evolutionary insights suggest that RoMV is a member of a novel species within genus tentatively named as South American mouse morbillivirus. Phylogenetic analysis suggests that this mouse morbillivirus is closely related to and clusters into a monophyletic group of novel rodent-borne morbilliviruses. This subclade of divergent viruses expands the host range, redefines the genomic organization and provides insights on the evolutionary history of genus .
副黏病毒科（order ）是单股负链 RNA 病毒，能感染包括人类、犬、猫、小反刍动物、海豹和鲸目动物在内的多种哺乳动物，这些动物是其自然宿主。在此，我报道了在南美毛足鼠和橄榄田鼠公共 RNAseq 数据集检测到的新型病毒的鉴定和特征。在从智利和阿根廷采集的鼠肾样本中检测到的这些被称为橄榄田鼠麻疹病毒（RoMV）的差异较大的病毒，其基因组包括长的基因间区和 F 与 H 基因之间的辅助蛋白，形成了 3'-N-P/V/C-M-F-hp-H-L-5' 的基因组结构。结构和功能注释、遗传距离和进化见解表明，RoMV 是属内一个新种的成员，暂命名为南美鼠麻疹病毒。系统发育分析表明，这种鼠麻疹病毒与新型啮齿动物传播的麻疹病毒密切相关，并聚类成一个单系群。这组差异较大的病毒扩展了宿主范围，重新定义了基因组组织，并为属的进化历史提供了新的见解。
