Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada.
J Vasc Res. 2023;60(2):114-124. doi: 10.1159/000527240. Epub 2022 Nov 10.
Pannexins (PANX1, 2, 3) are channel-forming glycoproteins that are expressed throughout the cardiovascular and musculoskeletal system. The canonical function of these proteins is to release nucleotides that act as purinergic signalling at the cell membrane or Ca2+ channels at the endoplasmic reticulum membrane. These two forms of signalling are essential for autocrine and paracrine signalling in health, and alterations in this signalling have been implicated in the pathogenesis of many diseases. Many musculoskeletal and cardiovascular diseases are largely the result of a lack of physical activity which causes altered gene expression. Considering exercise training has been shown to alter a wide array of gene expression in musculoskeletal tissues, understanding the interaction between exercise training, gene function and expression in relevant diseases is warranted. With regards to pannexins, multiple publications have shown that exercise training can influence pannexin expression and may influence the significance of its function in certain diseases. This review further discusses the potential interaction between exercise training and pannexin biology in relevant tissues and disease models. We propose that exercise training in relevant animal and human models will provide a more comprehensive understanding of the implications of pannexin biology in disease.
Pannexins（PANX1、2、3）是形成通道的糖蛋白，在心血管和肌肉骨骼系统中表达。这些蛋白质的典型功能是释放核苷酸，在细胞膜上作为嘌呤能信号，或在内质网膜上作为 Ca2+通道。这两种信号形式对于健康的自分泌和旁分泌信号至关重要，这种信号的改变与许多疾病的发病机制有关。许多肌肉骨骼和心血管疾病主要是由于缺乏体育活动导致基因表达改变的结果。考虑到运动训练已被证明可以改变肌肉骨骼组织中广泛的基因表达，因此，了解运动训练、基因功能和相关疾病中基因表达之间的相互作用是必要的。关于连接蛋白，多项研究表明，运动训练可以影响连接蛋白的表达，并可能影响其在某些疾病中的功能意义。这篇综述进一步讨论了运动训练和相关组织及疾病模型中连接蛋白生物学之间的潜在相互作用。我们提出，在相关动物和人类模型中进行运动训练将为连接蛋白生物学在疾病中的意义提供更全面的理解。
