Faculty of Education and Art, Sohar University, Sohar, 311, Sultanate of Oman
Faculty of Industrial Science and Technology, University Malaysia Pahang, Lebuhraya Tun Razak, 26300 Gambang, Kuantan, Pahang Darul Makmur, Malaysia
Comb Chem High Throughput Screen. 2023;26(11):1945-1959. doi: 10.2174/1386207326666221108095705.
SARS-CoV-2 is a disease that endangers both human life and the economy. There was an 11- month period of relative evolutionary standstill following the appearance of SARS-CoV-2 in late 2019. However, the emergence of clusters of mutations known as' variants of concern 'with variable viral properties such as transmissibility and antigenicity defined the evolution of SARS-CoV-2. Several efforts have been made in recent months to understand the atomic level properties of SARS-CoV-2. A review of the literature on SARS-CoV-2 mutations is offered in this paper. The critical activities performed by different domains of the SARS-CoV-2 genome throughout the virus's entry into the host and overall viral life cycle are discussed in detail. These structural traits may potentially pave the way for the development of a vaccine and medication to combat the SARS-CoV-2 sickness.
SARS-CoV-2 是一种既危害人类生命又危害经济的疾病。自 2019 年底 SARS-CoV-2 出现以来，经历了长达 11 个月的相对进化停滞期。然而，具有可变传染性和抗原性等病毒特性的“关注变种”突变簇的出现，定义了 SARS-CoV-2 的进化。近几个月来，人们已经做出了几次努力来了解 SARS-CoV-2 的原子水平特性。本文综述了 SARS-CoV-2 突变的文献。详细讨论了 SARS-CoV-2 基因组不同结构域在病毒进入宿主和整个病毒生命周期中所执行的关键活动。这些结构特征可能为开发疫苗和药物以对抗 SARS-CoV-2 疾病铺平道路。
