Department of Biophysics, Panjab University, Chandigarh 160014, India.
Department of Biophysics, Panjab University, Chandigarh 160014, India; UIPS, Panjab University, Chandigarh 160014, India.
Int J Biol Macromol. 2021 May 15;179:45-60. doi: 10.1016/j.ijbiomac.2021.02.212. Epub 2021 Mar 1.
Globally, SARS-CoV-2 has emerged as threat to life and economy. Researchers are trying to find a cure against this pathogen but without much success. Several attempts have been made to understand the atomic level details of SARS-CoV-2 in the past few months. However, one review with all structural details for drug and vaccine development has been missing. Hence, this review aims to summarize key functional roles played by various domains of SARS-CoV-2 genome during its entry into the host, replication, repression of host immune response and overall viral life cycle. Additionally, various proteins of SARS-CoV-2 for finding a potent inhibitor have also been highlighted. To mitigate this deadly virus, an understanding of atomic level information, pathogenicity mechanisms and functions of different proteins in causing the infection is imperative. Thus, these structural details would finally pave the way for development of a potential drug/vaccine against the disease caused by SARS-CoV-2.
从全球范围来看，SARS-CoV-2 已经对生命和经济构成威胁。研究人员正试图寻找针对这种病原体的治疗方法，但收效甚微。在过去的几个月里，人们已经做出了几次尝试来了解 SARS-CoV-2 的原子水平细节。然而，目前还缺少一份涵盖所有结构细节的关于药物和疫苗开发的综述。因此，本综述旨在总结 SARS-CoV-2 基因组的各个结构域在进入宿主、复制、抑制宿主免疫反应和整个病毒生命周期中所扮演的关键功能角色。此外，还强调了 SARS-CoV-2 的各种蛋白在寻找有效的抑制剂方面的作用。为了减轻这种致命病毒的危害，了解原子水平信息、不同蛋白在致病过程中的发病机制和功能至关重要。因此，这些结构细节最终将为开发针对 SARS-CoV-2 引起的疾病的潜在药物/疫苗铺平道路。
