Yang Chunxiu, Liang Jun
The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Science, No. 6 Taoyuan Road, Nanning, 530021, Guangxi, China.
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Environ Sci Pollut Res Int. 2023 Feb;30(10):26327-26337. doi: 10.1007/s11356-022-23997-4. Epub 2022 Nov 11.
Hematologic parameters are important indicators for monitoring the physiological changes and human health. Neonicotinoids (NEOs) exhibit toxic effects and can affect hematologic parameters. However, the effects of exposure to NEOs metabolites on hematologic parameters in the general population remain unknown. We examined the relationship between NEOs metabolites and hematologic parameters using a cross-sectional study design in 1397 adults of the National Health and Nutrition Examination Survey (NHANES) 2015-2016. The levels of NEOs metabolites in urine and hematologic makers were measured. Multivariate linear regression models were performed to examine the relationship between exposure to NEOs metabolites and hematologic parameters. Detectable urine levels of clothianidin (CLO) was inversely associated with hematocrit (β = - 0.689; 95% CI: - 1.335, - 0.042). Detectability of 5-hydroxy-imidacloprid (HIMI) was inversely correlated with basophil percentage (β = - 0.093; 95% CI: - 0.180, - 0.007). N-Desmethyl-acetamiprid (NDE) was related to reduced white blood cells (WBC) (β = - 0.419; 95% CI: - 0.764, - 0.074) and neutrophil counts (β = - 0.349; 95% CI: - 0.623, - 0.074). Imidacloprid-equivalent total neonicotinoids (IMIeq) was negatively related to red blood cells (RBC) (β = - 0.058; 95% CI: - 0.097, - 0.020), hemoglobin (β = - 0.149; 95% CI: - 0.282, - 0.015), and hematocrit (β = - 0.484; 95% CI: - 0.855, - 0.113). We also observed that exposure to NEOs metabolites was sex specifically related to hematologic alterations. For example, IMIeq was associated with reduced basophil counts (β = - 0.016; 95% CI: - 0.028, - 0.003), basophil percentage (β = - 0.092; 95% CI: - 0.169, - 0.016), RBC (β = - 0.097; 95% CI: - 0.156, - 0.038), hemoglobin (β = - 0.200; 95% CI: - 0.355, - 0.045), and hematocrit (β = - 0.605; 95% CI: - 1.111, - 0.098) only in males. These results provide the first evidence that exposure to NEOs metabolites can disturb hematologic homeostasis in the general population, and the effects may be sex specific.
血液学参数是监测生理变化和人类健康的重要指标。新烟碱类（NEOs）具有毒性作用，可影响血液学参数。然而，接触NEOs代谢物对普通人群血液学参数的影响尚不清楚。我们在2015 - 2016年美国国家健康与营养检查调查（NHANES）的1397名成年人中采用横断面研究设计，研究了NEOs代谢物与血液学参数之间的关系。测量了尿液中NEOs代谢物的水平和血液学指标。采用多元线性回归模型研究接触NEOs代谢物与血液学参数之间的关系。可检测到的噻虫胺（CLO）尿液水平与血细胞比容呈负相关（β = - 0.689；95%置信区间：- 1.335，- 0.042）。5 - 羟基吡虫啉（HIMI）的可检测性与嗜碱性粒细胞百分比呈负相关（β = - 0.093；95%置信区间：- 0.180，- 0.007）。N - 去甲基啶虫脒（NDE）与白细胞（WBC）减少（β = - 0.419；95%置信区间：- 0.764，- 0.074）和中性粒细胞计数减少（β = - 作0.349；95%置信区间：- 0.623，- 0.074）有关。吡虫啉当量总新烟碱类（IMIeq）与红细胞（RBC）（β = - 0.058；95%置信区间：- 作0.097，- 0.020）、血红蛋白（β = - 0.149；95%置信区间：- 0.282，- 0.015）和血细胞比容（β = - 0.484；95%置信区间：- 0.855，- 0.113）呈负相关。我们还观察到，接触NEOs代谢物与血液学改变存在性别特异性关系。例如，IMIeq仅与男性嗜碱性粒细胞计数减少（β = - 0.016；95%置信区间：- 0.028，- 0.003）、嗜碱性粒细胞百分比减少（β = - 0.092；95%置信区间：- 0.169，- 0.016）、RBC减少（β = - 0.097；95%置信区间：- 0.156，- 0.作038）、血红蛋白减少（β = - 0.200；95%置信区间：- 0.355，- 0.045）和血细胞比容减少（β = - 0.605；95%置信区间：- 1.111，- 0.098）有关。这些结果首次证明，接触NEOs代谢物会扰乱普通人群的血液学稳态，且这种影响可能具有性别特异性。
