Department of Physics, Faculty of Mathematical and Natural Science, IPB University (Bogor Agricultural University), Jalan Meranti, Building Wing S, 2nd Floor, Dramaga IPB Campus, 16680, Bogor, Indonesia.
J Biol Phys. 2022 Dec;48(4):439-459. doi: 10.1007/s10867-022-09618-8. Epub 2022 Nov 11.
Glioma is a human brain tumor that is very difficult to treat at an advanced stage. Studies of glioma biomarkers have shown that some markers are released into the bloodstream, so data from these markers indicate a decrease in the concentration of blood glucose and serum glucose in patients with glioma; these suggest an association between glucose and glioma. This decrease mechanism in glucose concentration can be described by the coupled ordinary differential equations of the early-stage glioma growth and interactions between glioma cells, immune cells, and glucose concentration. In this paper, we propose developing a new mathematical model to explain how glioma cells evolve and survive combination therapy between chemotherapy and oncolytic virotherapy, as an alternative to glioma treatment. In this study, three therapies were applied for analysis, that is, (1) chemotherapy, (2) virotherapy, and (3) a combination of chemotherapy and virotherapy. Virotherapy uses specialist viruses that only attack tumor cells. Based on the simulation results of the therapy carried out, we conclude that combination therapy can reduce the glioma cells significantly compared to the other two therapies. The simulation results of this combination therapy can be an alternative to glioma therapy.
脑胶质瘤是一种很难在晚期治疗的人类脑部肿瘤。脑胶质瘤生物标志物的研究表明，一些标志物被释放到血液中，因此这些标志物的数据表明脑胶质瘤患者的血糖和血清葡萄糖浓度降低；这表明葡萄糖与脑胶质瘤之间存在关联。葡萄糖浓度的这种降低机制可以通过早期脑胶质瘤生长和胶质瘤细胞、免疫细胞与葡萄糖浓度之间相互作用的耦合常微分方程来描述。在本文中，我们提出开发一个新的数学模型来解释化疗和溶瘤病毒治疗联合治疗如何使脑胶质瘤细胞进化和存活，作为脑胶质瘤治疗的替代方法。在这项研究中，分析了三种疗法，即（1）化疗，（2）病毒疗法，和（3）化疗和病毒疗法的联合。病毒疗法使用专门攻击肿瘤细胞的病毒。基于所进行的治疗模拟结果，我们得出结论，与其他两种疗法相比，联合疗法可以显著减少脑胶质瘤细胞。这种联合疗法的模拟结果可以作为脑胶质瘤治疗的一种替代方法。
