Spencer Drew A, Young Jacob S, Kanojia Deepak, Kim Julius W, Polster Sean P, Murphy Jason P, Lesniak Maciej S
Department of Neurosurgery, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Ther Deliv. 2015;6(4):453-68. doi: 10.4155/tde.14.123.
Malignant glioma is a relentless burden to both patients and clinicians, and calls for innovation to overcome the limitations in current management. Glioma therapy using viruses has been investigated to accentuate the nature of a virus, killing a host tumor cell during its replication. As virus mediated approaches progress with promising therapeutic advantages, combination therapy with chemotherapy and oncolytic viruses has emerged as a more synergistic and possibly efficacious therapy. Here, we will review malignant glioma as well as prior experience with oncolytic viruses, chemotherapy and combination of the two, examining how the combination can be optimized in the future.
恶性胶质瘤对患者和临床医生来说都是一个沉重的负担，需要创新来克服当前治疗方法的局限性。利用病毒进行胶质瘤治疗的研究旨在强化病毒的特性，使其在复制过程中杀死宿主肿瘤细胞。随着病毒介导的治疗方法不断取得具有前景的治疗优势，化疗与溶瘤病毒的联合治疗已成为一种更具协同效应且可能有效的治疗方法。在此，我们将回顾恶性胶质瘤以及此前溶瘤病毒、化疗及其联合治疗的经验，探讨未来如何优化这种联合治疗。
