Zhou Ning, Zhao Ye, Zhang Lingang, Ning Yuebao
School of Life Science, Inner Mongolia University, Hohhot 010020, PR China.
School of Life Science, Inner Mongolia University, Hohhot 010020, PR China.
Int J Biol Macromol. 2022 Dec 31;223(Pt A):378-390. doi: 10.1016/j.ijbiomac.2022.11.055. Epub 2022 Nov 9.
In this study, the synergistic effects of black onion on the hypolipidemic and antioxidant activities in T2DM rats induced by a high-fat-diet and alloxan were investigated. The results showed that the fasting blood glucose of diabetic rats was significantly decreased after treatment with black onion polysaccharide (p < 0.01). Blood lipid analysis indicated that black onion polysaccharide could significantly improve the abnormal metabolism of blood lipids caused by diabetes. In addition, the MDA and ROS of the diabetic rats treated with black onion polysaccharide were significantly reduced; moreover, SOD was increased, indicating the excellent antioxidant activity of black onion polysaccharide. A histological examination clearly showed that black onion polysaccharide could improve the histological morphology of the liver and kidney. Furthermore, the indices of liver and kidney function were restored. These results indicate that black onion polysaccharide can reduce blood glucose and simultaneously show synergistic effects of hypoglycemic and antioxidant activities in diabetic rats. Therefore, black onion polysaccharide may alleviate liver and kidney function injury by improving the "two-hit" mechanism and can thus be used as a potential functional food to prevent diabetes and its complications.
本研究考察了黑洋葱对高脂饮食和四氧嘧啶诱导的T2DM大鼠的降血脂及抗氧化活性的协同作用。结果表明，用黑洋葱多糖处理后，糖尿病大鼠的空腹血糖显著降低（p < 0.01）。血脂分析表明，黑洋葱多糖可显著改善糖尿病引起的血脂代谢异常。此外，用黑洋葱多糖处理的糖尿病大鼠的丙二醛（MDA）和活性氧（ROS）显著降低；而且，超氧化物歧化酶（SOD）增加，表明黑洋葱多糖具有优异的抗氧化活性。组织学检查清楚地表明，黑洋葱多糖可改善肝脏和肾脏的组织形态。此外，肝功能和肾功能指标得以恢复。这些结果表明，黑洋葱多糖可降低血糖，并同时在糖尿病大鼠中显示出降血糖和抗氧化活性的协同作用。因此，黑洋葱多糖可能通过改善“二次打击”机制减轻肝肾损伤，从而可作为预防糖尿病及其并发症的潜在功能性食品。
