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治疗药物监测和基于生理的药代动力学建模中的唾液采样：综述

Saliva Sampling in Therapeutic Drug Monitoring and Physiologically Based Pharmacokinetic Modeling: Review.

作者信息

Almukainzi May

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

出版信息

Drug Res (Stuttg). 2023 Feb;73(2):65-69. doi: 10.1055/a-1956-9313. Epub 2022 Nov 11.

DOI:10.1055/a-1956-9313
PMID:36368679
Abstract

Therapeutic drug monitoring investigations based on saliva samples can be utilized as an alternative to blood sampling for many advantages. Moreover, the development of physiologically based pharmacokinetic (PBPK) modeling tools can further help to estimate drug exposure from saliva. This review discusses the use of saliva samples and illustrates the applications and examples of PBPK modeling systems for estimating drug exposure from saliva.

摘要

基于唾液样本的治疗药物监测研究因其诸多优势可作为血液采样的替代方法。此外，基于生理的药代动力学（PBPK）建模工具的发展能够进一步助力从唾液中估算药物暴露量。本综述讨论了唾液样本的使用，并举例说明了用于从唾液中估算药物暴露量的PBPK建模系统的应用。

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