益生菌补充剂预防妊娠期糖尿病：随机对照试验的荟萃分析
Probiotic Supplement for the Prevention of Gestational Diabetes: A Meta-Analysis of Randomized Controlled Trials.
作者信息
Zhang Zengliang, Niu Renxiu, Zhang Huixin, Ma Teng, Chen Xuexia, Pan Linlin
机构信息
Traditinal Chinese Medicine College, Inner Mongolia Medical University, Jinshan Economic & Technology Development Zone, Hohhot, Inner Mongolia, China.
Nursing School of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
出版信息
Z Geburtshilfe Neonatol. 2023 Feb;227(1):24-30. doi: 10.1055/a-1956-3927. Epub 2022 Nov 11.
BACKGROUND
Probiotic supplements may have some potential in preventing gestational diabetes, and this meta-analysis aims to explore the efficacy of probiotic supplements to prevent gestational diabetes.
METHODS
PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of probiotic supplements on the incidence of gestational diabetes mellitus. Meta-analysis was performed using the fixed-effect or random-effect model as appropriate.
RESULTS
Six RCTs were finally included in the meta-analysis. Overall, compared with control intervention in pregnant women, probiotic supplementation intervention showed no obvious impact on the incidence of gestational diabetes (OR=0.68; 95% CI=0.39 to 1.20; P=0.18), fasting plasma glucose (SMD=-0.05; 95% CI=-0.29 to 0.19; P=0.69), 2 h-OGTT (SMD=-0.07; 95% CI=-0.27 to 0.13; P=0.47), gestational age (SMD=0.04; 95% CI=-0.14 to 0.21; P=0.69) or preeclampsia (OR=1.22; 95% CI=0.83 to 1.78; P=0.31).
CONCLUSIONS
Probiotic supplementation was confirmed to have no benefits for the prevention of gestational diabetes.
背景
益生菌补充剂在预防妊娠期糖尿病方面可能具有一定潜力，本荟萃分析旨在探讨益生菌补充剂预防妊娠期糖尿病的疗效。
方法
系统检索了PubMed、EMbase、Web of science、EBSCO和Cochrane图书馆数据库，纳入评估益生菌补充剂对妊娠期糖尿病发病率影响的随机对照试验（RCT）。根据情况使用固定效应或随机效应模型进行荟萃分析。
结果
最终有6项RCT纳入荟萃分析。总体而言，与孕妇的对照干预相比，补充益生菌干预对妊娠期糖尿病的发病率（OR=0.68；95%CI=0.39至1.20；P=0.18）、空腹血糖（SMD=-0.05；95%CI=-0.29至0.19；P=0.69）、2小时口服葡萄糖耐量试验（SMD=-0.07；95%CI=-0.27至0.13；P=0.47）、孕周（SMD=0.04；95%CI=-0.14至0.21；P=0.69）或子痫前期（OR=1.22；95%CI=0.83至1.78；P=0.31）均无明显影响。
结论
证实补充益生菌对预防妊娠期糖尿病无益处。
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