Ding Hao, Droby Amgad, Anwar Abdul Rauf, Bange Manuel, Hausdorff Jeffrey M, Nasseroleslami Bahman, Mirelman Anat, Maidan Inbal, Groppa Sergiu, Muthuraman Muthuraman
Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Academic Unit of Neurology, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
NPJ Parkinsons Dis. 2022 Nov 11;8(1):153. doi: 10.1038/s41531-022-00427-3.
Treadmill training (TT) has been extensively used as an intervention to improve gait and mobility in patients with Parkinson's disease (PD). Regional and global effects on brain activity could be induced through TT. Training effects can lead to a beneficial shift of interregional connectivity towards a physiological range. The current work investigates the effects of TT on brain activity and connectivity during walking and at rest by using both functional near-infrared spectroscopy and functional magnetic resonance imaging. Nineteen PD patients (74.0 ± 6.59 years, 13 males, disease duration 10.45 ± 6.83 years) before and after 6 weeks of TT, along with 19 age-matched healthy controls were assessed. Interregional effective connectivity (EC) between cortical and subcortical regions were assessed and its interrelation to prefrontal cortex (PFC) activity. Support vector regression (SVR) on the resting-state ECs was used to predict prefrontal connectivity. In response to TT, EC analysis indicated modifications in the patients with PD towards the level of healthy controls during walking and at rest. SVR revealed cerebellum related connectivity patterns that were associated with the training effect on PFC. These findings suggest that the potential therapeutic effect of training on brain activity may be facilitated via changes in compensatory modulation of the cerebellar interregional connectivity.
跑步机训练（TT）已被广泛用作一种干预手段，以改善帕金森病（PD）患者的步态和运动能力。通过跑步机训练可以诱导对大脑活动的局部和整体影响。训练效果可导致区域间连接朝着生理范围产生有益的转变。当前的研究工作通过使用功能近红外光谱和功能磁共振成像，调查了跑步机训练对行走和休息期间大脑活动及连接性的影响。对19名帕金森病患者（年龄74.0 ± 6.59岁，男性13名，病程10.45 ± 6.83年）在进行6周跑步机训练前后，以及19名年龄匹配的健康对照者进行了评估。评估了皮质和皮质下区域之间的区域间有效连接（EC）及其与前额叶皮质（PFC）活动的相互关系。使用基于静息态有效连接的支持向量回归（SVR）来预测前额叶连接性。针对跑步机训练，有效连接分析表明，帕金森病患者在行走和休息时的有效连接朝着健康对照者的水平发生了改变。支持向量回归揭示了与小脑相关的连接模式，这些模式与对前额叶皮质的训练效果相关。这些发现表明，训练对大脑活动的潜在治疗效果可能通过小脑区域间连接的代偿性调节变化而得到促进。
