Institute of Gastroenterology, Marmara University, İstanbul, Turkey.
Department of Gastroenterology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
Aliment Pharmacol Ther. 2023 Jan;57(2):215-223. doi: 10.1111/apt.17301. Epub 2022 Nov 11.
Patients with non-alcoholic fatty liver disease (NAFLD) and more advanced fibrosis tend to have more impairment in their health-related quality of life and other patient-reported outcomes (PROs).
To assess the association of PROs with select non-invasive tests (NITs) for fibrosis including FAST, Agile 3+ and Agile 4 scores METHODS: We enrolled patients with an established diagnosis of NAFLD who were seen in a tertiary care clinic into the NAFLD/NASH Registry. The FAST, Agile 3+ and Agile 4 scores were calculated using liver stiffness measurements by transient elastography and laboratory parameters. PROs were assessed using FACIT-F, CLDQ-NASH and WPAI instruments (total of 17 domain and summary scores).
There were 1509 patients with NAFLD (mean age: 49 ± 11 years, 50% men, 41% employed, 30% advanced fibrosis and 20% cirrhosis). The mean FAST, Agile 3+ and Agile 4 scores were 0.39 ± 0.26, 0.35 ± 0.31 and 0.12 ± 0.23, respectively. Subjects with lower FAST, Agile 3+ and Agile 4 scores had the highest scores in select domains of FACIT-F, CLDQ-NASH and WPAI (p < 0.05 in comparison to subjects with elevated or high-risk NIT scores). Correlations with continuous NITs were significantly negative for Emotional and Functional well-being (FACIT-F), Activity/energy, Systemic symptoms, Worry and total scores (CLDQ-NASH), and Activity of WPAI (p < 0.05); the strongest was for Worry (CLDQ-NASH) with FAST (R = -0.17, p < 0.0001). The PRO scores of patients with NAFLD were lower than those of matched patients with chronic hepatitis B (p < 0.05 for 9/17 domain and summary scores).
Patients with NAFLD and high FAST, Agile 3+ or Agile 4 scores experience impairment of health-related quality of life.
非酒精性脂肪性肝病（NAFLD）和更严重纤维化的患者往往在健康相关生活质量和其他患者报告的结果（PRO）方面受损更多。
评估 PRO 与包括 FAST、Agile 3+和 Agile 4 评分在内的几种纤维化的非侵入性检测（NIT）之间的关联。
我们招募了在三级护理诊所就诊的已确诊为 NAFLD 的患者，纳入 NAFLD/NASH 登记处。通过瞬态弹性成像和实验室参数计算 FAST、Agile 3+和 Agile 4 评分。使用 FACIT-F、CLDQ-NASH 和 WPAI 工具评估 PRO（共 17 个领域和总结评分）。
共有 1509 名 NAFLD 患者（平均年龄：49±11 岁，50%为男性，41%在职，30%有晚期纤维化，20%有肝硬化）。平均 FAST、Agile 3+和 Agile 4 评分分别为 0.39±0.26、0.35±0.31 和 0.12±0.23。FAST、Agile 3+和 Agile 4 评分较低的患者在 FACIT-F、CLDQ-NASH 和 WPAI 的某些领域中得分最高（与评分升高或高风险的 NIT 相比，p<0.05）。与连续 NIT 的相关性在情绪和功能健康（FACIT-F）、活动/能量、全身症状、担忧和总分（CLDQ-NASH）和 WPAI 的活动方面呈显著负相关（p<0.05）；最强的是与 FAST（CLDQ-NASH）的担忧（R=-0.17，p<0.0001）。NAFLD 患者的 PRO 评分低于慢性乙型肝炎患者（9/17 个领域和总结评分的 p<0.05）。
NAFLD 患者的 FAST、Agile 3+或 Agile 4 评分较高，其健康相关生活质量受损。
