Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
J Cereb Blood Flow Metab. 2023 Mar;43(3):476-478. doi: 10.1177/0271678X221139550. Epub 2022 Nov 11.
Long-lasting activities with high demand in cognitive control are known to result in cognitive fatigue. However, the reason for control cost inflation remains elusive. A neurometabolic account was proposed in a recent study combining magnetic resonance spectroscopy (MRS) with daylong execution of behavioral tasks. It suggests that control cost during high-demand work is related to the necessity of recycling potentially toxic substances, specifically glutamate, which may accumulate extracellularly. As MRS provides estimates of metabolite concentrations, further evaluations are possible how well this hypothesis fits with fundamental consequences from the dynamic equilibrium of intercompartmental glutamate distributions.
长时间、高认知控制需求的活动会导致认知疲劳。然而，控制成本增加的原因仍不清楚。最近的一项研究结合磁共振波谱（MRS）和全天执行行为任务，提出了一种神经代谢解释。该研究认为，高需求工作期间的控制成本与回收潜在毒性物质（特别是谷氨酸）的必要性有关，谷氨酸可能会在细胞外积累。由于 MRS 可以估计代谢物浓度，因此可以进一步评估该假设与细胞外谷氨酸分布的动态平衡所带来的基本后果之间的吻合程度。
